3-(2-ethyl-2H-tetrazol-5-yl)aniline(SALTDATA: FREE)

Base Information

• Chemical Name: 3-(2-ethyl-2H-tetrazol-5-yl)aniline(SALTDATA: FREE)
• CAS No.: 1082766-28-6
• Molecular Formula: C9H11N5
• Molecular Weight: 189.22
• Mol file: 1082766-28-6.mol

Synonyms:3-(2-ethyl-2H-tetrazol-5-yl)aniline(SALTDATA: FREE)

Chemical Property of 3-(2-ethyl-2H-tetrazol-5-yl)aniline(SALTDATA: FREE)

Chemical Property:

• PSA: 69.62000
• LogP: 1.52340

Purity/Quality:

98% ^*data from raw suppliers

3-(2-Ethyl-2H-tetrazol-5-yl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-ethyl-2H-tetrazol-5-yl)aniline(SALTDATA: FREE)

There total 4 articles about 3-(2-ethyl-2H-tetrazol-5-yl)aniline(SALTDATA: FREE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-ethyl-5-(3-nitrophenyl)-2H-tetrazole → C9H11N5 (1082766-28-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 3h;

DOI:10.1002/adsc.202000475

Reference yield:

2-ethyl-5-phenyl-2H-tetrazole (31818-94-7) → C9H11N5 (1082766-28-6)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(II) nitrate trihydrate; bis-[(trifluoroacetoxy)iodo]benzene; triphenylphosphine; dodecacarbonyl-triangulo-triruthenium / 24 h / 100 °C / Sealed tube

2: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C

With dodecacarbonyl-triangulo-triruthenium; copper(II) nitrate trihydrate; palladium 10% on activated carbon; hydrogen; triphenylphosphine; bis-[(trifluoroacetoxy)iodo]benzene; In methanol;

DOI:10.1002/adsc.202000475

Reference yield:

5-phenyl-2H-1,2,3,4-tetrazole (18039-42-4) → C9H11N5 (1082766-28-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / 0.08 h / 20 °C

1.2: 4 h / 85 °C

2.1: dodecacarbonyl-triangulo-triruthenium; triphenylphosphine; bis-[(trifluoroacetoxy)iodo]benzene; copper(II) nitrate trihydrate / 24 h / 100 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol

With dodecacarbonyl-triangulo-triruthenium; copper(II) nitrate trihydrate; palladium 10% on activated carbon; hydrogen; potassium carbonate; triphenylphosphine; bis-[(trifluoroacetoxy)iodo]benzene; In methanol;

DOI:10.1039/d0ra06405j

upstream raw materials:

2-ethyl-5-phenyl-2H-tetrazole

5-phenyl-2H-1,2,3,4-tetrazole

benzonitrile

Refernces

• 1、 Yan, Yu-Hang,Chen, Jian,Zhan, Zhen,Yu, Zhu-Jun,Li, Gen,Guo, Li,Li, Guo-Bo,Wu, Yong,Zheng, Yongxiang. "Discovery of mercaptopropanamide-substituted aryl tetrazoles as new broad-spectrum metallo-β-lactamase inhibitors". . p. 31377 - 31384. Retrieved 2020/09/21.