Technology Process of Propanoic acid, 2,2-dimethyl-, octahydro-1,6,7-trihydroxy-8-indolizinyl ester, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)-
There total 4 articles about Propanoic acid, 2,2-dimethyl-, octahydro-1,6,7-trihydroxy-8-indolizinyl ester, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.)Bu2SnO, 2.) Bu4NBr, 3.) LiH, Pr-SH / 1.) MePh, reflux, 2 h, 2.) MePh, reflux, 3 days, 3.) DMSO, 3 h
2: 63 percent / pyridine / 30 h / 70 °C
3: 74 percent / H2 / 20percent Pd(OH)2/C / acetic acid / 24 h / 2327.2 Torr
With
pyridine; 1-thiopropane; tetrabutylammomium bromide; hydrogen; lithium hydride; di(n-butyl)tin oxide;
palladium dihydroxide;
In
acetic acid;
DOI:10.1016/0040-4020(95)00803-G
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 63 percent / pyridine / 30 h / 70 °C
2: 74 percent / H2 / 20percent Pd(OH)2/C / acetic acid / 24 h / 2327.2 Torr
With
pyridine; hydrogen;
palladium dihydroxide;
In
acetic acid;
DOI:10.1016/0040-4020(95)00803-G