1-(1-(tert-Butoxycarbonyl)piperidin-4-yl)-1H-pyrazol-4-ylboronic acid

Base Information

• Chemical Name: 1-(1-(tert-Butoxycarbonyl)piperidin-4-yl)-1H-pyrazol-4-ylboronic acid
• CAS No.: 1190875-39-8
• Molecular Formula: C13H22BN3O4
• Molecular Weight: 295.146
• Hs Code.: 2933990090
• Mol file: 1190875-39-8.mol

Synonyms:1-(1-(tert-Butoxycarbonyl)piperidin-4-yl)-1H-pyrazol-4-ylboronic acid;1-(1-BOC-Piperidino)pyrazole-4-boronic acid;1-(Boc-piperidin-4-yl)-pyrazole-4-boronate;1-(1-Boc-piperidin-4-yl)-pyrazole-4-boronic acid

Chemical Property of 1-(1-(tert-Butoxycarbonyl)piperidin-4-yl)-1H-pyrazol-4-ylboronic acid

Chemical Property:

• Boiling Point: 481.5±55.0 °C(Predicted)
• PKA: 7.66±0.10(Predicted)
• PSA: 87.82000
• Density: 1.24±0.1 g/cm3(Predicted)
• LogP: 0.07280
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-(Boc-piperidin-4-yl)-pyrazole-4-boronate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(1-(tert-Butoxycarbonyl)piperidin-4-yl)-1H-pyrazol-4-ylboronic acid is used in the preparation of triazolopyrazine derivatives for treating hyperproliferative disorders. 1-(Boc-piperidin-4-yl)-pyrazole-4-boronate is used in the preparation of triazolopyrazine derivatives for treating hyperproliferative disorders.

Technology Process of 1-(1-(tert-Butoxycarbonyl)piperidin-4-yl)-1H-pyrazol-4-ylboronic acid

There total 3 articles about 1-(1-(tert-Butoxycarbonyl)piperidin-4-yl)-1H-pyrazol-4-ylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester (877399-50-3) + 2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1195-66-0) + water (7732-18-5) → (1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-1H-pyrazol-4-yl)boronic acid (1190875-39-8)

Guidance literature:

4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester; With isopropylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 12h; Autoclave; Large scale;

2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In tetrahydrofuran; for 12h; Large scale;

water; With ammonium chloride; In tetrahydrofuran; Large scale;

Reference yield:

tert-butyl 4-(4-iodo-1H-pyrazol-1-yl)piperidine-1-carboxylate (877399-73-0) + 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (61676-62-8) + water (7732-18-5) → (1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-1H-pyrazol-4-yl)boronic acid (1190875-39-8)

Guidance literature:

tert-butyl 4-(4-iodo-1H-pyrazol-1-yl)piperidine-1-carboxylate; With isopropylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 12h; Autoclave; Large scale;

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In tetrahydrofuran; for 12h; Large scale;

water; With ammonium chloride; In tetrahydrofuran; Large scale;

Reference yield:

tert-butyl 4-(4-iodo-1H-pyrazol-1-yl)piperidine-1-carboxylate (877399-73-0) + Trimethyl borate (121-43-7,63156-11-6) + water (7732-18-5) → (1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-1H-pyrazol-4-yl)boronic acid (1190875-39-8)

Guidance literature:

tert-butyl 4-(4-iodo-1H-pyrazol-1-yl)piperidine-1-carboxylate; With isopropylmagnesium chloride; In tetrahydrofuran; at 20 - 25 ℃; for 12h; Autoclave; Large scale;

Trimethyl borate; In tetrahydrofuran; at 25 ℃; for 12h; Large scale;

water; With ammonium chloride; In tetrahydrofuran; Large scale;

upstream raw materials:

4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester

2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

water

tert-butyl 4-(4-iodo-1H-pyrazol-1-yl)piperidine-1-carboxylate

Downstream raw materials:

4-(4-{6-amino-5-[(R)-1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-pyrazol-1-yl)-piperidine-1-carboxylic acid tert-butyl ester

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