13-Isopropyl-12-methoxypodocarpa-8,11,13-trien-20-oic acid methyl ester

Base Information

Chemical Name:13-Isopropyl-12-methoxypodocarpa-8,11,13-trien-20-oic acid methyl ester
CAS No.:57397-34-9
Molecular Formula:C₂₂H₃₂O₃
Molecular Weight:344.494
Hs Code.:
Mol file:57397-34-9.mol

Synonyms:13-Isopropyl-12-methoxypodocarpa-8,11,13-trien-20-oic acid methyl ester

Suppliers and Price of 13-Isopropyl-12-methoxypodocarpa-8,11,13-trien-20-oic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 13-Isopropyl-12-methoxypodocarpa-8,11,13-trien-20-oic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 13-Isopropyl-12-methoxypodocarpa-8,11,13-trien-20-oic acid methyl ester

There total 1 articles about 13-Isopropyl-12-methoxypodocarpa-8,11,13-trien-20-oic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 562-13-0
2,2-dimethyl-1,3-cyclohexanedione

: 57397-34-9
(+)-methyl (5S,10R)-12-methoxyabieta-8,11,13-trien-20-oate

Guidance literature:: Multi-step reaction with 17 steps

1: baker's yeast

3: NaH, KH / dioxane / 1.17 h / Heating

4: 93.2 percent / NaOMe / methanol; benzene / 2 h / Ambient temperature

5: 84.8 percent / pyrrolidine / benzene / 22 h / Heating

6: 51.4 percent / p-TsOH / methanol / 4 h / Ambient temperature

7: 1.) KOH / 1.) MeOH, H₂O, room temp., 5 h; 2.) EtOAc, ether, 0 deg C, 2 min

8: 88.7 percent / DMAP, TfCl / CH₂Cl₂ / 15 min at 0 deg C then 1 h at room temp.

9: PtO₂, H₂ / ethyl acetate / 36 h / Ambient temperature

10: 80 percent / Jones reagent / acetone / 0.17 h / Ambient temperature

11: NaH / benzene / 1 h at 5 deg C and 20 h at room temp.

12: DDQ, AcOH / dioxane / 0.25 h / Ambient temperature

13: NaH / benzene / 0.75 h / Ambient temperature

14: 84.2 percent / p-TsOH / acetic acid / 3.5 h / Heating

15: C₅H₅NHBr₃ / acetic acid / 1 h / Ambient temperature

16: 89.3 percent / 10percent , H₂,Pd-C, conc. H₂SO₄ / ethyl acetate / 13 h / 35 °C

17: 81.9 percent / anh. K₂CO₃ / acetone / 17 h / Heating

With pyrrolidine; dmap; platinum(IV) oxide; potassium hydroxide; palladium on activated charcoal; jones reagent; trifluoromethane sulfonyl chloride; sulfuric acid; hydrogen; sodium methylate; potassium hydride; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; acetic acid; pyridinium hydrobromide perbromide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; methanol; dichloromethane; acetic acid; ethyl acetate; acetone; benzene;
DOI:10.1016/S0040-4020(01)88156-4

Reference yield: 93.0%

: 57397-34-9,62076-04-4,110716-61-5
methyl 12-methoxyabieta-8,11,13-trien-20-oate

: 67494-15-9,83150-89-4
(+/-)-pisiferic acid

Guidance literature:: With aluminum tri-bromide; ethanethiol; for 13h; Ambient temperature;
DOI:10.1246/bcsj.55.1599

Reference yield:

: 57397-34-9
(+)-methyl (5S,10R)-12-methoxyabieta-8,11,13-trien-20-oate

: 57397-33-8
12-methoxyabieta-8,11,13-trien-20-al

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / diethyl ether / 20 h / Ambient temperature

2: CrO₃ / acetone / 0.05 h / 0 °C

With chromium(VI) oxide; lithium aluminium tetrahydride; In diethyl ether; acetone;
DOI:10.1016/S0031-9422(00)82465-6