(R)-α,α-Bis(4-fluorophenyl)-2-pyrrolidineMethanol

Base Information Edit

Chemical Name:(R)-α,α-Bis(4-fluorophenyl)-2-pyrrolidineMethanol
CAS No.:1198225-48-7
Molecular Formula:C17H17F2NO
Molecular Weight:289.3197864
Hs Code.:
Mol file:1198225-48-7.mol

Synonyms:(R)-α,α-Bis(4-fluorophenyl)-2-pyrrolidineMethanol

Suppliers and Price of (R)-α,α-Bis(4-fluorophenyl)-2-pyrrolidineMethanol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of (R)-α,α-Bis(4-fluorophenyl)-2-pyrrolidineMethanol Edit

Chemical Property:

PSA：32.26000
LogP:3.28150

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-α,α-Bis(4-fluorophenyl)-2-pyrrolidineMethanol

There total 2 articles about (R)-α,α-Bis(4-fluorophenyl)-2-pyrrolidineMethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1370292-91-3
(R)-ethyl 2-(bis(4-fluorophenyl)(hydroxy)methyl)pyrrolidine-1-carboxylate

: 1198225-48-7
(R)-bis(4-fluorophenyl)(pyrrolidin-2-yl)methanol

Guidance literature:: With methanol; potassium hydroxide; for 12h; Reflux;
DOI:10.1021/jm201627n

Reference yield:

: 352-13-6
4-flourophenylmagnesium bromide

: 1198225-48-7
(R)-bis(4-fluorophenyl)(pyrrolidin-2-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 3 h / 0 °C

2: methanol; potassium hydroxide / 12 h / Reflux

With methanol; potassium hydroxide; In tetrahydrofuran;
DOI:10.1021/jm201627n