5-Methyl-3-(4-nitrophenyl)isoxazole-4-carboxylic acid

Base Information

Chemical Name:5-Methyl-3-(4-nitrophenyl)isoxazole-4-carboxylic acid
CAS No.:7123-64-0
Molecular Formula:C₁₁H₈N₂O₅
Molecular Weight:248.195
Hs Code.:
DSSTox Substance ID:DTXSID10591398
Wikidata:Q82485157

Synonyms:7123-64-0;5-METHYL-3-(4-NITROPHENYL)ISOXAZOLE-4-CARBOXYLIC ACID;SCHEMBL7763901;DTXSID10591398;AKOS015935774;DA-37116;5-methyl-3-(4-nitrophenyl)-1,2-oxazole-4-carboxylic acid;5-METHYL-3-(4-NITROPHENYL)ISOXAZOLE-4-CARBOXYLICACID

Suppliers and Price of 5-Methyl-3-(4-nitrophenyl)isoxazole-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 5-Methyl-3-(4-nitrophenyl)isoxazole-4-carboxylic acid

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:248.04332136
Heavy Atom Count:18
Complexity:335

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=NO1)C2=CC=C(C=C2)[N+](=O)[O-])C(=O)O

Technology Process of 5-Methyl-3-(4-nitrophenyl)isoxazole-4-carboxylic acid

There total 4 articles about 5-Methyl-3-(4-nitrophenyl)isoxazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7035-82-7
5-methyl-3-(4-nitro-phenyl)-isoxazole-4-carboxylic acid ethyl ester

: 7123-64-0
5-methyl-3-(4-nitrophenyl)isoxazole-4-carboxylic acid

Guidance literature:: With aq. alcali; In ethanol; for 12h; Ambient temperature;

Reference yield:

: 1129-37-9,174848-02-3,20707-69-1
4-nitrobenzaldehyde oxime

: 7123-64-0
5-methyl-3-(4-nitrophenyl)isoxazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: (i) Cl₂, CHCl₃, (ii) /BRN= 4161430/, EtOH

2: aq. alcali / ethanol / 12 h / Ambient temperature

With aq. alcali; In ethanol;

Reference yield:

: 1011-84-3
4-nitrobenzohydroximoyl chloride

: 7123-64-0
5-methyl-3-(4-nitrophenyl)isoxazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: NaOMe / methanol

2: aq. HCl / acetic acid

With hydrogenchloride; sodium methylate; In methanol; acetic acid;
DOI:10.1039/jr9630005845