3-iodobenzeneethanol

Base Information

• Chemical Name: 3-iodobenzeneethanol
• CAS No.: 127201-31-4
• Molecular Formula: C₈H₉IO
• Molecular Weight: 248.063
• Mol file: 127201-31-4.mol

Synonyms:3-iodobenzeneethanol

Chemical Property of 3-iodobenzeneethanol

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-iodobenzeneethanol

There total 4 articles about 3-iodobenzeneethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-iodophenylacetic acid (1878-69-9) → 2-(3-iodophenyl)ethan-1-ol (127201-31-4)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

Reference yield: 67.0%

2-(3-aminophenyl)ethan-1-ol (52273-77-5) → 2-(3-iodophenyl)ethan-1-ol (127201-31-4)

Guidance literature:

2-(3-aminophenyl)ethan-1-ol; With sulfuric acid; sodium nitrite; In water; at 0 ℃; for 0.5h;

With potassium iodide; In water; at 0 - 60 ℃; for 2.5h;

DOI:10.1021/acs.jmedchem.0c01710

Reference yield:

2-(3-nitrophenyl)ethanol (52022-77-2) → 2-(3-iodophenyl)ethan-1-ol (127201-31-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 6 h / 20 °C / Schlenk technique

2.1: sulfuric acid; sodium nitrite / water / 0.5 h / 0 °C

2.2: 2.5 h / 0 - 60 °C

With sulfuric acid; palladium 10% on activated carbon; hydrogen; sodium nitrite; In methanol; water;

DOI:10.1021/acs.jmedchem.0c01710

upstream raw materials:

3-iodophenylacetic acid

2-(3-aminophenyl)ethan-1-ol

2-(3-nitrophenyl)ethanol

Downstream raw materials:

2-(3-iodophenyl)ethyl bromide

2-[3-(6-benzyloxy-pyridazin-3-ylethynyl)-phenyl]-ethanol

1-[2-(benzyloxy)ethyl]-3-iodobenzene

2-[3-[5-[[1-(benzyloxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]ethanol