Tyrosyl-alanyl-glycyl-methylphenylalanine-2-(1-oxopropyl)hydrazide

Base Information

Chemical Name:Tyrosyl-alanyl-glycyl-methylphenylalanine-2-(1-oxopropyl)hydrazide
CAS No.:72732-46-8
Molecular Formula:C₂₇H₃₆N₆O₆
Molecular Weight:540.619
Hs Code.:
DSSTox Substance ID:DTXSID80993547
Wikidata:Q82984244
Mol file:72732-46-8.mol

Synonyms:EK 209;EK 209, monoacetate salt;EK-209;Tyr-Ala-Gly-MePhe-NHNHCOCH2CH3;tyrosyl-alanyl-glycyl-methylphenylalanine-2-(1-oxopropyl)hydrazide

Suppliers and Price of Tyrosyl-alanyl-glycyl-methylphenylalanine-2-(1-oxopropyl)hydrazide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Tyrosyl-alanyl-glycyl-methylphenylalanine-2-(1-oxopropyl)hydrazide

Chemical Property:

PSA：182.96000
LogP:1.77390
XLogP3:0.9
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:12
Exact Mass:540.26963289
Heavy Atom Count:39
Complexity:841

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC(=O)NNC(=O)C(CC1=CC=CC=C1)N(C)C(=O)CNC(=O)C(C)NC(=O)C(CC2=CC=C(C=C2)O)N
Isomeric SMILES:CCC(=O)NNC(=O)[C@H](CC1=CC=CC=C1)N(C)C(=O)CNC(=O)[C@@H](C)NC(=O)[C@H](CC2=CC=C(C=C2)O)N

Technology Process of Tyrosyl-alanyl-glycyl-methylphenylalanine-2-(1-oxopropyl)hydrazide

There total 6 articles about Tyrosyl-alanyl-glycyl-methylphenylalanine-2-(1-oxopropyl)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74085-25-9
[(S)-1-{(R)-1-[({[(S)-1-Benzyl-2-oxo-2-(N'-propionyl-hydrazino)-ethyl]-methyl-carbamoyl}-methyl)-carbamoyl]-ethylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid benzyl ester

: 72732-46-8
(S)-2-Amino-N-{(R)-1-[({[(S)-1-benzyl-2-oxo-2-(N'-propionyl-hydrazino)-ethyl]-methyl-carbamoyl}-methyl)-carbamoyl]-ethyl}-3-(4-hydroxy-phenyl)-propionamide

Guidance literature:: With hydrogen; palladium; In methanol;
DOI:10.1248/cpb.29.3639

Reference yield:

: 2439-60-3,27442-39-3
N-methyl-L-phenylalanine methyl ester

: 72732-46-8
(S)-2-Amino-N-{(R)-1-[({[(S)-1-benzyl-2-oxo-2-(N'-propionyl-hydrazino)-ethyl]-methyl-carbamoyl}-methyl)-carbamoyl]-ethyl}-3-(4-hydroxy-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: HONB, DCC / dimethylformamide / 1.) 0 deg C, 5 h, 2.) r.t.

2: 82 percent / NH₂NH₂*H₂O / methanol / Ambient temperature

3: 87 percent / HOBT, DCC / dimethylformamide / 1.) 0 deg C, 5 h, 2.) r.t.

4: 110 mg / hydrogen / Pd-black / methanol

With hydrogen; benzotriazol-1-ol; hydrazine hydrate; dicyclohexyl-carbodiimide; (3aR,4R,7S,7aS)-2-hydroxy-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione (N-hydroxy-5-exo-norbornene-2,3-dicarboximide); palladium; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.29.3639

Reference yield:

: 2899-07-2
(S)-N-benzyloxycarbonyl-N-methyl-phenyl alanine

: 72732-46-8
(S)-2-Amino-N-{(R)-1-[({[(S)-1-benzyl-2-oxo-2-(N'-propionyl-hydrazino)-ethyl]-methyl-carbamoyl}-methyl)-carbamoyl]-ethyl}-3-(4-hydroxy-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 6 steps

1: 5 N HCl-dioxane

2: hydrogen / Pd-black / methanol

3: HONB, DCC / dimethylformamide / 1.) 0 deg C, 5 h, 2.) r.t.

4: 82 percent / NH₂NH₂*H₂O / methanol / Ambient temperature

5: 87 percent / HOBT, DCC / dimethylformamide / 1.) 0 deg C, 5 h, 2.) r.t.

6: 110 mg / hydrogen / Pd-black / methanol

With hydrogenchloride; hydrogen; benzotriazol-1-ol; hydrazine hydrate; dicyclohexyl-carbodiimide; (3aR,4R,7S,7aS)-2-hydroxy-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione (N-hydroxy-5-exo-norbornene-2,3-dicarboximide); palladium; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.29.3639