1-Piperidinecarboxylic acid, 4-[[3-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]phenyl]Methylene]-, 1,1-diMethylethyl ester

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 4-[[3-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]phenyl]Methylene]-, 1,1-diMethylethyl ester
CAS No.:1020325-45-4
Molecular Formula:C23H25F3N2O3
Molecular Weight:434.458
Hs Code.:
Mol file:1020325-45-4.mol

Synonyms:1-Piperidinecarboxylic acid, 4-[[3-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]phenyl]Methylene]-, 1,1-diMethylethyl ester

Suppliers and Price of 1-Piperidinecarboxylic acid, 4-[[3-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]phenyl]Methylene]-, 1,1-diMethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
tert-Butyl4-(3-((5-(Trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxylate
50mg
$ 200.00

Total 6 raw suppliers

Chemical Property of 1-Piperidinecarboxylic acid, 4-[[3-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]phenyl]Methylene]-, 1,1-diMethylethyl ester

Chemical Property:

Boiling Point:511.6±50.0 °C(Predicted)
PKA:0.74±0.22(Predicted)
PSA：51.66000
Density:1.241±0.06 g/cm3(Predicted)
LogP:6.24490

Purity/Quality:

NLT 98% ^*data from raw suppliers

tert-Butyl4-(3-((5-(Trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses tert-Butyl 4-(3-((5-(Trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxylate is used as a reactant in the synthesis of novel spirocyclic FAAH inhibitors.

Technology Process of 1-Piperidinecarboxylic acid, 4-[[3-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]phenyl]Methylene]-, 1,1-diMethylethyl ester

There total 5 articles about 1-Piperidinecarboxylic acid, 4-[[3-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]phenyl]Methylene]-, 1,1-diMethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1020325-38-5
2-[3-(diethoxyphosphorylmethyl)phenoxy]-5-(trifluoromethyl)pyridine

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1020325-45-4
4-[3-(5-trifluoromethyl-pyridin-2-yloxy)-benzylidene]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran;
DOI:10.1021/ml100190t

Reference yield:

: 1020325-30-7
2-[3-(chIoromethyl)phenoxy]-5-(trifluoromethyl)pyridine

: 1020325-45-4
4-[3-(5-trifluoromethyl-pyridin-2-yloxy)-benzylidene]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 16 h / 130 °C

2: potassium tert-butylate / tetrahydrofuran

With potassium tert-butylate; In tetrahydrofuran; 2: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/ml100190t

Reference yield:

: 1020325-22-7
[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methanol

: 1020325-45-4
4-[3-(5-trifluoromethyl-pyridin-2-yloxy)-benzylidene]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / dichloromethane / 2 h / 20 °C

2: 16 h / 130 °C

3: potassium tert-butylate / tetrahydrofuran

With thionyl chloride; potassium tert-butylate; In tetrahydrofuran; dichloromethane; 3: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/ml100190t