Methyl 3-aMinocyclobutanecarboxylate

Base Information

• Chemical Name: Methyl 3-aMinocyclobutanecarboxylate
• CAS No.: 1206970-19-5
• Molecular Formula: C6H11NO2
• Molecular Weight: 129.15704
• Hs Code.: 2922499990
• Mol file: 1206970-19-5.mol

Synonyms:Methyl 3-aMinocyclobutanecarboxylate;Cyclobutanecarboxylic acid,3-amino-,methyl ester

Chemical Property of Methyl 3-aMinocyclobutanecarboxylate

Chemical Property:

• Boiling Point: 169.1±33.0 °C(Predicted)
• PKA: 10.19±0.40(Predicted)
• PSA: 52.32000
• Density: 1.111±0.06 g/cm3(Predicted)
• LogP: 0.59700
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

99%min. ^*data from raw suppliers

Methyl3-aminocyclobutanecarboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 3-aMinocyclobutanecarboxylate

There total 16 articles about Methyl 3-aMinocyclobutanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl 3-((tert-butoxycarbonyl)amino)cyclobutanecarboxylate (1101173-77-6) → methyl 3-aminocyclobutane-1-carboxylate (1206970-19-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.5b01917

Reference yield: 78.0%

methanol (67-56-1) + 3-aminocyclobutanecarboxylic acid hydrochloride → methyl 3-aminocyclobutane-1-carboxylate (1206970-19-5)

Guidance literature:

With thionyl chloride; at 0 - 50 ℃; for 2h;

Reference yield:

(1s,3s)-methyl 3-((tert-butoxycarbonyl)amino)cyclobutane-carboxylate (1101173-77-6) → (1s,3s)-methyl 3-aminocyclobutanecarboxylate (1206970-19-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 1.5h;

upstream raw materials:

cis-methyl 3-azidocyclobutanecarboxylate

trans-methyl 3-azidocyclobutanecarboxylate

3-chlorocyclobutane-1-carboxylic acid

cyclobutane-1,1'-dicarboxylic acid

Downstream raw materials:

cis-3-aminocyclobutane-1-carboxylic acid

(1r,3r)-3-aminocyclobutane-1-carboxylic acid

Refernces

• 1、 Jordan, John B.,Whittington, Douglas A.,Bartberger, Michael D.,Sickmier, E. Allen,Chen, Kui,Cheng, Yuan,Judd, Ted. "Fragment-Linking Approach Using 19F NMR Spectroscopy to Obtain Highly Potent and Selective Inhibitors of β-Secretase". . p. 3732 - 3749. Retrieved 2016/05/19.
• 2、 Radchenko, Dmytro S.,Tkachenko, Anton,Grygorenko, Oleksandr O.,Komarov, Igor V.. "Expedient synthesis of cis- and trans-3-aminocyclobutanecarboxylic acids". experimental part. p. 1644 - 1649. Retrieved 2011/06/23.