Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(2-methyl-1-oxopropyl)-6-O-[2-(4-nitrophenyl)ethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Base Information

• Chemical Name: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(2-methyl-1-oxopropyl)-6-O-[2-(4-nitrophenyl)ethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
• CAS No.: 102691-37-2
• Molecular Formula: C₅₂H₆₁N₈O₁₀P
• Molecular Weight: 989.078
• DSSTox Substance ID: DTXSID401099317
• Nikkaji Number: J1.246.159C
• Mol file: 102691-37-2.mol

Synonyms:DTXSID401099317;102691-37-2

Chemical Property of Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(2-methyl-1-oxopropyl)-6-O-[2-(4-nitrophenyl)ethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Chemical Property:

• XLogP3: 8.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 15
• Rotatable Bond Count: 23
• Exact Mass: 988.42482717
• Heavy Atom Count: 71
• Complexity: 1640

Purity/Quality:

99%,98%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)C(=O)NC1=NC2=C(C(=N1)OCCC3=CC=C(C=C3)[N+](=O)[O-])N=CN2C4CC(C(O4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OP(N(C(C)C)C(C)C)OCCC#N
• Isomeric SMILES: CC(C)C(=O)NC1=NC2=C(C(=N1)OCCC3=CC=C(C=C3)[N+](=O)[O-])N=CN2[C@H]4C[C@@H]([C@H](O4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OP(N(C(C)C)C(C)C)OCCC#N

Technology Process of Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(2-methyl-1-oxopropyl)-6-O-[2-(4-nitrophenyl)ethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

There total 2 articles about Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(2-methyl-1-oxopropyl)-6-O-[2-(4-nitrophenyl)ethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) + 5'-O-dimethoxytrityl-N2-isobutyryl-O6-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine (90678-72-1) → 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N2-isobutyryl-O6-[2-(4-nitrophenyl)ethyl]guanosine 3'-(2-cyanoethyl diisopropylphosphoramidite) (102691-37-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1002/(SICI)1522-2675(19991215)82:12<2172::AID-HLCA2172>3.0.CO;2-R

Reference yield:

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) + 5'-O-dimethoxytrityl-N2-isobutyryl-O6-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine (90678-72-1) → 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N2-isobutyryl-O6-[2-(4-nitrophenyl)ethyl]guanosine 3'-(2-cyanoethyl diisopropylphosphoramidite) (102691-37-2)

Guidance literature:

With 1H-tetrazole; In chloroform; acetonitrile; at 25 ℃; for 0.5h;

upstream raw materials:

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

5'-O-dimethoxytrityl-N²-isobutyryl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine