N2,N2-Bis(carboxyMethyl) N6-Boc-

Base Information

• Chemical Name: N2,N2-Bis(carboxyMethyl) N6-Boc-
• CAS No.: 752200-93-4
• Molecular Formula: C15H26N2O8
• Molecular Weight: 362.37554
• Mol file: 752200-93-4.mol

Synonyms:N2,N2-Bis(carboxyMethyl) N6-Boc-;N2,N2-Bis(carboxyMethyl) N6-Boc-L-lysine

Chemical Property of N2,N2-Bis(carboxyMethyl) N6-Boc-

Chemical Property:

• Boiling Point: 614.8±55.0 °C(Predicted)
• PKA: 1.68±0.10(Predicted)
• PSA: 156.96000
• Density: 1.294±0.06 g/cm3(Predicted)
• LogP: 0.81020

Purity/Quality:

97% ^*data from raw suppliers

N2,N2-Bis(carboxymethyl)N6-Boc-L-lysine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N2,N2-Bis(carboxyMethyl) N6-Boc-L-lysine can be used for the preparation of amino acid derivatives as metal ion chelating agents

Technology Process of N2,N2-Bis(carboxyMethyl) N6-Boc-

There total 2 articles about N2,N2-Bis(carboxyMethyl) N6-Boc- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(S)-2-amino-6-(tert-butoxycarbonylamino)hexanoic acid (2418-95-3) + bromoacetic acid (79-08-3) → 2-[bis(carboxymethylamino)]-6-tert-butoxycarbonylaminohexanoic acid (752200-93-4)

Guidance literature:

(S)-2-amino-6-(tert-butoxycarbonylamino)hexanoic acid; bromoacetic acid; With sodium hydroxide; In water; at 0 - 50 ℃; for 19h; Inert atmosphere;

With hydrogenchloride; In water; at 0 - 5 ℃; pH=2;

DOI:10.1002/chem.200901213

Reference yield: 64.0%

di-tert-butyl dicarbonate (24424-99-5) + N,N-bis(carboxymethyl)-L-lysine (113231-05-3) → 2-[bis(carboxymethylamino)]-6-tert-butoxycarbonylaminohexanoic acid (752200-93-4)

Guidance literature:

With sodium hydrogencarbonate; In water; acetonitrile; at 20 ℃; for 24h;

DOI:10.1002/anie.201203255

Reference yield: 51.0%

2-[bis(carboxymethylamino)]-6-tert-butoxycarbonylaminohexanoic acid (752200-93-4) + benzyl bromide (100-39-0) → 2-[bis(benzyloxycarbonylmethylamino)]-6-tert-butoxycarbonylaminohexanoic acid benzyl ester (637331-39-6)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 24h; Inert atmosphere;

DOI:10.1002/chem.200901213

upstream raw materials:

(S)-2-amino-6-(tert-butoxycarbonylamino)hexanoic acid

bromoacetic acid

di-tert-butyl dicarbonate

N,N-bis(carboxymethyl)-L-lysine

Downstream raw materials:

2-[bis(benzyloxycarbonylmethylamino)]-6-tert-butoxycarbonylaminohexanoic acid benzyl ester