2-(2-Methoxyethoxy)aniline

Base Information

• Chemical Name: 2-(2-Methoxyethoxy)aniline
• CAS No.: 72806-66-7
• Molecular Formula: C9H13 N O2
• Molecular Weight: 167.208
• Hs Code.: 2922190090
• European Community (EC) Number: 276-852-4
• DSSTox Substance ID: DTXSID20993607
• Nikkaji Number: J318.834E
• Wikidata: Q82984301
• Mol file: 72806-66-7.mol

Synonyms:2-(2-Methoxyethoxy)aniline;72806-66-7;2-(2-Methoxy-ethoxy)-phenylamine;2-(2-Methoxyethoxy)-benzenamine;EINECS 276-852-4;Benzenamine,2-(2-methoxyethoxy)-;2-(2-methoxyethoxy)phenylamine;2-(2-methoxy)ethoxyaniline;SCHEMBL1029928;2-(2-Methoxyethoxy)benzenamine;AMY4647;DTXSID20993607;GGVZNGYEHJHVMK-UHFFFAOYSA-N;[2-(2-methoxyethoxy)phenyl]amine;MFCD08144123;AKOS000100284;FS-5672;2-(2-Methoxyethoxy)aniline, AldrichCPR;CS-0150166;FT-0712120;EN300-54521;C78424;Z274541842

Chemical Property of 2-(2-Methoxyethoxy)aniline

Chemical Property:

• Vapor Pressure: 0.00353mmHg at 25°C
• Boiling Point: 281.6°C at 760 mmHg
• Flash Point: 134.8°C
• PSA: 44.48000
• Density: 1.078g/cm³
• LogP: 1.87520
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 167.094628657
• Heavy Atom Count: 12
• Complexity: 119

Purity/Quality:

98%min ^*data from raw suppliers

2-(2-Methoxyethoxy)aniline ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCOC1=CC=CC=C1N

Technology Process of 2-(2-Methoxyethoxy)aniline

There total 7 articles about 2-(2-Methoxyethoxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(2-methoxyethoxy)-2-nitro-benzene (62819-95-8) → 2-(2-methoxyethoxy)phenylamine (72806-66-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 18h; under 1672.11 Torr;

DOI:10.1021/ja0284761

Reference yield:

2-hydroxynitrobenzene (88-75-5,78813-12-4) → 2-(2-methoxyethoxy)phenylamine (72806-66-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / K₂CO₃; KI / dimethylformamide / 6 h / 110 °C

2: 95 percent / H₂ / Pd/C / methanol / 18 h / 1672.11 Torr

With hydrogen; potassium carbonate; potassium iodide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/ja0284761

Reference yield:

2-methoxyethoxy anisidine → 2-(2-methoxyethoxy)phenylamine (72806-66-7)

Guidance literature:

palladium; In methanol;

upstream raw materials:

1-(2-methoxyethoxy)-2-nitro-benzene

2-hydroxynitrobenzene

2-(acetylamino)phenol

2-(2-hydroxyethoxy)nitrobenzene

Downstream raw materials:

2,2'-((2-(2-methoxyethoxy)phenyl)azanediyl)diethanol

N-[2-(2-methoxyethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide

N-(4-azido-2-methoxyethoxyphenyl)aza-[18]crown-6 ether

N-(4-amino-2-methoxyethoxyphenyl)aza-[18]crown-6 ether