1-(2-Methoxyethoxy)-2-nitrobenzene

Base Information

• Chemical Name: 1-(2-Methoxyethoxy)-2-nitrobenzene
• CAS No.: 62819-95-8
• Molecular Formula: C9H11NO4
• Molecular Weight: 197.191
• Hs Code.: 2909309090
• European Community (EC) Number: 263-737-9
• DSSTox Substance ID: DTXSID50978508
• Nikkaji Number: J307.136G
• Wikidata: Q82963911
• Mol file: 62819-95-8.mol

Synonyms:1-(2-methoxyethoxy)-2-nitrobenzene;62819-95-8;beta-Methoxy-2-nitrophenetole;EINECS 263-737-9;2-Methoxyethoxynitrobenzene;SCHEMBL1340747;2-(2-methoxy)ethoxynitrobenzene;DTXSID50978508;DJTJGNJDSIOAOS-UHFFFAOYSA-N;2-(2-Methoxyethoxy)-1-nitrobenzene;MFCD16877751;BS-29235;CS-0208852

Chemical Property of 1-(2-Methoxyethoxy)-2-nitrobenzene

Chemical Property:

• Boiling Point: 316.5°Cat760mmHg
• Flash Point: 146.5°C
• PSA: 64.28000
• Density: 1.197g/cm³
• LogP: 2.14320
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 197.06880783
• Heavy Atom Count: 14
• Complexity: 180

Purity/Quality:

99% ^*data from raw suppliers

1-(2-Methoxyethoxy)-2-nitrobenzene 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCOC1=CC=CC=C1[N+](=O)[O-]

Technology Process of 1-(2-Methoxyethoxy)-2-nitrobenzene

There total 7 articles about 1-(2-Methoxyethoxy)-2-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-Bromoethyl methyl ether (6482-24-2) + 2-hydroxynitrobenzene (88-75-5,78813-12-4) → 1-(2-methoxyethoxy)-2-nitro-benzene (62819-95-8)

Guidance literature:

With potassium carbonate; potassium iodide; In acetonitrile; at 90 ℃;

Reference yield: 81.0%

2-chloroethyl methyl ether (627-42-9) + 2-hydroxynitrobenzene (88-75-5,78813-12-4) → 1-(2-methoxyethoxy)-2-nitro-benzene (62819-95-8)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 110 ℃; for 6h;

DOI:10.1021/ja0284761

Reference yield:

methyl 1-chloroethyl ether (1538-87-0) + 2-hydroxynitrobenzene (88-75-5,78813-12-4) → 1-(2-methoxyethoxy)-2-nitro-benzene (62819-95-8)

Guidance literature:

With Ki; potassium carbonate; In chloroform; water; N,N-dimethyl-formamide;

upstream raw materials:

2-chloroethyl methyl ether

2-hydroxynitrobenzene

methyl 1-chloroethyl ether

2-methoxy-ethyl p-toluenesulfonyloxy ester

Downstream raw materials:

C₄₅H₅₈N₆O₁₀

C₄₆H₅₈N₆O₁₂

C₁₉H₂₀N₂O₂

C₂₅H₂₈FN₃O₃

Refernces

• 1、 Nitta, Aiko,Iura, Yosuke,Inoue, Hideki,Imaoka, Takayuki,Takahashi, Toshiya,Sato, Ippei,Morihira, Koichiro,Kubota, Hirokazu,Morokata, Tatsuaki,Takeuchi, Makoto,Ohta, Mitsuaki,Tsukamoto, Shin-Ichi. "Pyrrolidinyl phenylurea derivatives as novel CCR3 antagonists". . p. 6876 - 6881,6. Retrieved 2020/09/02.
• 2、 Wang, Xuehua,Cao, Jing,Chen, Chuanfeng. "A Highly efficient and selective turn-on fluorescent sensor for Cu2+ ion". scheme or table. p. 1777 - 1779. Retrieved 2011/07/09.