[2-(2-methoxy-ethoxy)-phenyl]-bis-[2-(5-methyl-2-nitro-phenoxy)-ethyl]-amine

Base Information

• Chemical Name: [2-(2-methoxy-ethoxy)-phenyl]-bis-[2-(5-methyl-2-nitro-phenoxy)-ethyl]-amine
• CAS No.: 328267-54-5
• Molecular Formula: C₂₇H₃₁N₃O₈
• Molecular Weight: 525.558
• Mol file: 328267-54-5.mol

Synonyms:[2-(2-methoxy-ethoxy)-phenyl]-bis-[2-(5-methyl-2-nitro-phenoxy)-ethyl]-amine

Chemical Property of [2-(2-methoxy-ethoxy)-phenyl]-bis-[2-(5-methyl-2-nitro-phenoxy)-ethyl]-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-(2-methoxy-ethoxy)-phenyl]-bis-[2-(5-methyl-2-nitro-phenoxy)-ethyl]-amine

There total 4 articles about [2-(2-methoxy-ethoxy)-phenyl]-bis-[2-(5-methyl-2-nitro-phenoxy)-ethyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-(2-methoxyethoxy)phenylamine (72806-66-7) + 1-bromo-2-(2'-nitro-5'-methylphenoxy)ethane (96315-07-0) → [2-(2-methoxy-ethoxy)-phenyl]-bis-[2-(5-methyl-2-nitro-phenoxy)-ethyl]-amine (328267-54-5)

Guidance literature:

With calcium carbonate; potassium iodide; In 1,4-dioxane; water; for 36h; Inert atmosphere; Reflux;

DOI:10.1002/ejoc.201403600

Reference yield:

1-(2-methoxyethoxy)-2-nitro-benzene (62819-95-8) → [2-(2-methoxy-ethoxy)-phenyl]-bis-[2-(5-methyl-2-nitro-phenoxy)-ethyl]-amine (328267-54-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / H₂ / Pd/C / methanol / 18 h / 1672.11 Torr

2: 55 percent / K₂CO₃; KI / acetonitrile / 60 h / Heating

With hydrogen; potassium carbonate; potassium iodide; palladium on activated charcoal; In methanol; acetonitrile;

DOI:10.1021/ja0284761

Reference yield:

2-hydroxynitrobenzene (88-75-5,78813-12-4) → [2-(2-methoxy-ethoxy)-phenyl]-bis-[2-(5-methyl-2-nitro-phenoxy)-ethyl]-amine (328267-54-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / K₂CO₃; KI / dimethylformamide / 6 h / 110 °C

2: 95 percent / H₂ / Pd/C / methanol / 18 h / 1672.11 Torr

3: 55 percent / K₂CO₃; KI / acetonitrile / 60 h / Heating

With hydrogen; potassium carbonate; potassium iodide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/ja0284761

upstream raw materials:

2-(2-methoxyethoxy)phenylamine

1-bromo-2-(2'-nitro-5'-methylphenoxy)ethane

2-nitro-5-methylphenol

1-(2-methoxyethoxy)-2-nitro-benzene

Downstream raw materials:

C₄₅H₅₈N₆O₁₀

C₄₆H₅₈N₆O₁₂

C₆₅H₇₉N₅O₁₂

TAC-NH₂