3-BROMO-6-CHLORO-2-FLUOROPHENOL

Base Information

• Chemical Name: 3-BROMO-6-CHLORO-2-FLUOROPHENOL
• CAS No.: 943830-14-6
• Molecular Formula: C6H3BrClFO
• Molecular Weight: 225.445
• Hs Code.: 2908199090
• Mol file: 943830-14-6.mol

Synonyms:3-BROMO-6-CHLORO-2-FLUOROPHENOL

Chemical Property of 3-BROMO-6-CHLORO-2-FLUOROPHENOL

Chemical Property:

• Boiling Point: 211.6±35.0 °C(Predicted)
• PKA: 6.27±0.15(Predicted)
• PSA: 20.23000
• Density: 1.875±0.06 g/cm3(Predicted)
• LogP: 2.94720
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-6-chloro-2-fluorophenol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMO-6-CHLORO-2-FLUOROPHENOL

There total 1 articles about 3-BROMO-6-CHLORO-2-FLUOROPHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-bromo-4-chloro-2-fluorobenzene (1996-29-8) → 3-bromo-6-chloro-2-fluorophenol (943830-14-6)

Guidance literature:

1-bromo-4-chloro-2-fluorobenzene; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃; for 0.5h;

With Trimethyl borate; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 - -20 ℃; for 1h;

With peracetic acid; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 - 20 ℃; for 12h;

Reference yield: 78.0%

3-bromo-6-chloro-2-fluorophenol (943830-14-6) + methyl iodide (74-88-4) → 1-bromo-4-chloro-2-fluoro-3-methoxybenzene (943832-96-0)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; Reflux;

Reference yield: 77.0%

3-bromo-6-chloro-2-fluorophenol (943830-14-6) + tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate (143900-44-1) → (R)-tert-butyl 3-(3-bromo-6-chloro-2- fluorophenoxy)piperidine-1-carboxylate

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 23 ℃; for 16h;

DOI:10.1021/acs.jmedchem.0c01020

upstream raw materials:

1-bromo-4-chloro-2-fluorobenzene

Downstream raw materials:

1-bromo-4-chloro-2-fluoro-3-methoxybenzene

2-(4-chloro-2-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

N-(4-(4-chloro-2-fluoro-3-methoxyphenyl)-5-formylpyridin-2-yl)acetamide

N-(4-(4-chloro-2-fluoro-3-methoxyphenyl)-5-(hydroxymethyl)pyridin-2-yl)acetamide

Refernces

• 1、 -. "ARYL LACTAM KINASE INHIBITORS". Page/Page column 260. . Retrieved 2015/11/02.
• 2、 -. "Aryl Ether-Base Kinase Inhibitors". Page/Page column 0290. . Retrieved 2013/09/26.