1-(5-CHLORO-THIOPHEN-2-YL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE

Base Information

Chemical Name:1-(5-CHLORO-THIOPHEN-2-YL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE
CAS No.:326-73-8
Molecular Formula:C₈H₄ClF₃O₂S
Molecular Weight:256.633
Hs Code.:2934999090
Mol file:326-73-8.mol

Synonyms:AKOS B010031;1-(5-CHLORO-THIOPHEN-2-YL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE;ART-CHEM-BB B010031;1-(5-CHLORO-2-THIENYL)-4,4,4-TRIFLUORO-1,3-BUTANEDIONE

Suppliers and Price of 1-(5-CHLORO-THIOPHEN-2-YL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
1-(5-Chlorothiophen-2-yl)-4,4,4-trifluorobutane-1,3-dione 95+%
1g
$ 583.00

Arctom
1-(5-Chlorothiophen-2-yl)-4,4,4-trifluorobutane-1,3-dione 98%
1g
$ 341.00

American Custom Chemicals Corporation
1-(5-CHLORO-THIOPHEN-2-YL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE 95.00%
1G
$ 318.15

AK Scientific
1-(5-Chlorothiophen-2-yl)-4,4,4-trifluorobutane-1,3-dione
1g
$ 407.00

AK Scientific
1-(5-Chlorothiophen-2-yl)-4,4,4-trifluorobutane-1,3-dione
500mg
$ 305.00

Total 8 raw suppliers

Chemical Property of 1-(5-CHLORO-THIOPHEN-2-YL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE

Chemical Property:

Boiling Point:307.3±42.0 °C(Predicted)
PKA:5.31±0.25(Predicted)
PSA：62.38000
Density:1.519±0.06 g/cm3(Predicted)
LogP:3.10570

Purity/Quality:

97% ^*data from raw suppliers

1-(5-Chlorothiophen-2-yl)-4,4,4-trifluorobutane-1,3-dione 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-(5-CHLORO-THIOPHEN-2-YL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE

There total 1 articles about 1-(5-CHLORO-THIOPHEN-2-YL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6310-09-4
2-acetyl-5-chlorothiophene

: 383-63-1
ethyl trifluoroacetate,

: 326-73-8
1-(5-chloro-[2]thienyl)-4,4,4-trifluoro-butane-1,3-dione

Guidance literature:: With diethyl ether; sodium methylate;
DOI:10.1021/ja01154a037

Reference yield:

: 326-73-8
1-(5-chloro-[2]thienyl)-4,4,4-trifluoro-butane-1,3-dione

: 1068105-55-4
3-{1-[4-(5-chlorothiophen-2-yl)-6-trifluoromethylpyrimidin-2-yl]-1H-imidazol-4-yl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / methanol / 40 h / Heating / reflux

2: trichlorophosphate / N,N-dimethyl-formamide / 16 h / 115 °C

3: potassium carbonate / N,N-dimethyl-formamide / 0.75 h / 130 °C

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 20 °C / Heating / reflux

5: trifluoroacetic acid / dichloromethane / 15 h / 20 °C

With hydrogenchloride; sodium carbonate; potassium carbonate; trifluoroacetic acid; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl-formamide; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 326-73-8
1-(5-chloro-[2]thienyl)-4,4,4-trifluoro-butane-1,3-dione

: 1068105-63-4
N-tert-butyl-3-{1-[4-(5-chlorothiophen-2-yl)-6-trifluoromethylpyrimidin-2-yl]-1H-imidazol-4-yl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / methanol / 40 h / Heating / reflux

2: trichlorophosphate / N,N-dimethyl-formamide / 16 h / 115 °C

3: potassium carbonate / N,N-dimethyl-formamide / 0.75 h / 130 °C

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 20 °C / Heating / reflux

With hydrogenchloride; sodium carbonate; potassium carbonate; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl-formamide; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;