2-(Isopropylamino)pyrimidine-5-carboxylic acid

Base Information

Chemical Name:2-(Isopropylamino)pyrimidine-5-carboxylic acid
CAS No.:148741-64-4
Molecular Formula:C₈H₁₁N₃O₂
Molecular Weight:181.194
Hs Code.:
DSSTox Substance ID:DTXSID60599288
Wikidata:Q82495161
Mol file:148741-64-4.mol

Synonyms:148741-64-4;2-(ISOPROPYLAMINO)PYRIMIDINE-5-CARBOXYLIC ACID;2-(propan-2-ylamino)pyrimidine-5-carboxylic acid;2-Isopropylamino-5-carboxypyrimidine;5-Pyrimidinecarboxylic acid, 2-[(1-methylethyl)amino]-;SCHEMBL200700;2-[(Propan-2-yl)amino]pyrimidine-5-carboxylic acid;DTXSID60599288;KHKCJJIQFAWEGW-UHFFFAOYSA-N;MFCD09864452;AKOS000284193;SB56818;BS-35727;DB-149047;CS-0205732;2-(Isopropylamino)-5-pyrimidinecarboxylic acid;2-(ISOPROPYLAMINO)PYRIMIDINE-5-CARBOXYLICACID;2-[(1-Methylethyl)amino]-5-pyrimidinecarboxylic acid

Suppliers and Price of 2-(Isopropylamino)pyrimidine-5-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(isopropylamino)pyrimidine-5-carboxylicacid
100mg
$ 65.00

ChemBridge Corporation
2-(isopropylamino)pyrimidine-5-carboxylicacid 95%
5 g
$ 205.00

American Custom Chemicals Corporation
2-(ISOPROPYLAMINO)PYRIMIDINE-5-CARBOXYLIC ACID 95.00%
10G
$ 2279.97

American Custom Chemicals Corporation
2-(ISOPROPYLAMINO)PYRIMIDINE-5-CARBOXYLIC ACID 95.00%
5G
$ 1491.68

American Custom Chemicals Corporation
2-(ISOPROPYLAMINO)PYRIMIDINE-5-CARBOXYLIC ACID 95.00%
1G
$ 818.61

Total 5 raw suppliers

Chemical Property of 2-(Isopropylamino)pyrimidine-5-carboxylic acid

Chemical Property:

Vapor Pressure:3.67E-06mmHg at 25°C
Boiling Point:371.1°C at 760 mmHg
Flash Point:178.2°C
PSA：75.11000
Density:1.282g/cm³
LogP:1.06810
XLogP3:0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:181.085126602
Heavy Atom Count:13
Complexity:176

Purity/Quality:

98% ^*data from raw suppliers

2-(isopropylamino)pyrimidine-5-carboxylicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)NC1=NC=C(C=N1)C(=O)O

Technology Process of 2-(Isopropylamino)pyrimidine-5-carboxylic acid

There total 2 articles about 2-(Isopropylamino)pyrimidine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 148741-62-2
2-isopropylamino-5-methoxycarbonylpyrimidine

: 148741-64-4
2-Isopropylamino-5-carboxypyrimidine

Guidance literature:: With sodium hydroxide; In methanol; water;

Reference yield:

: 77476-95-0
(5-bromopyrimidin-2-yl)-N-isopropylamine

: 148741-64-4
2-Isopropylamino-5-carboxypyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide / 12 h / 100 °C

2: lithium hydroxide; water / tetrahydrofuran; methanol / 3 h / 20 °C

With water; palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm500007h

Reference yield: 30.0%

: 148741-64-4
2-Isopropylamino-5-carboxypyrimidine

: 1202649-62-4
3-amino-4-methyl-N-(4-((4-methylpiperazin-1-yl) methyl)-3-(trifluoromethyl)phenyl)benzamide

: 1581701-28-1
2-(isopropylamino)-N-(2-methyl-5-((4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamoyl)phenyl)pyrimidine-5-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/jm500007h