4-(4-methylphenyl)-1-oxo-1H-isochromene-3-carboxylic acid

Base Information

• Chemical Name: 4-(4-methylphenyl)-1-oxo-1H-isochromene-3-carboxylic acid
• CAS No.: 53904-41-9
• Molecular Formula: C17H12O4
• Molecular Weight: 280.28
• Hs Code.: 2932209090
• Mol file: 53904-41-9.mol

Synonyms:4-(4-methylphenyl)-1-oxo-1H-isochromene-3-carboxylic acid

Chemical Property of 4-(4-methylphenyl)-1-oxo-1H-isochromene-3-carboxylic acid

Chemical Property:

• PSA: 67.51000
• LogP: 3.46660

Purity/Quality:

98%min ^*data from raw suppliers

4-(4-Methylphenyl)-1-oxo-1H-isochromene-3-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-methylphenyl)-1-oxo-1H-isochromene-3-carboxylic acid

There total 3 articles about 4-(4-methylphenyl)-1-oxo-1H-isochromene-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2-(4-toluoyl)benzoic acid (85-55-2) + Diethyl 2-bromomalonate (685-87-0) → 4-(4-methylphenyl)-1-oxo-1H-isochromene-3-carboxylic acid (53904-41-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; acetone; at 20 ℃;

DOI:10.1021/jm0603163

Reference yield:

1-Oxo-4-p-tolyl-1H-isochromene-3-carboxylic acid ethyl ester (94224-72-3) → 4-(4-methylphenyl)-1-oxo-1H-isochromene-3-carboxylic acid (53904-41-9)

Guidance literature:

With hydrogenchloride; In acetic acid;

DOI:10.1016/j.tetlet.2009.02.089

Reference yield:

→ 4-(4-methylphenyl)-1-oxo-1H-isochromene-3-carboxylic acid (53904-41-9)

Guidance literature:

Cumarin 1d, HCl;

upstream raw materials:

2-(4-toluoyl)benzoic acid

Diethyl 2-bromomalonate

1-Oxo-4-p-tolyl-1H-isochromene-3-carboxylic acid ethyl ester

Downstream raw materials:

1,2-dihydro-4-(4-methylphenyl)-2-methyl-1-oxo-3-isoquinolinecarboxylic acid

C₁₇H₁₃NO₃

ethyl 1,2-dihydro-4-(4-methylphenyl)-2-methyl-1-oxo-3-isoquinolinecarboxylate

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