1,2-dihydro-4-(4-methylphenyl)-2-methyl-1-oxo-3-isoquinolinecarboxylic acid

Base Information

Chemical Name:1,2-dihydro-4-(4-methylphenyl)-2-methyl-1-oxo-3-isoquinolinecarboxylic acid
CAS No.:912564-21-7
Molecular Formula:C₁₈H₁₅NO₃
Molecular Weight:293.322
Hs Code.:

Synonyms:1,2-dihydro-4-(4-methylphenyl)-2-methyl-1-oxo-3-isoquinolinecarboxylic acid

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Chemical Property of 1,2-dihydro-4-(4-methylphenyl)-2-methyl-1-oxo-3-isoquinolinecarboxylic acid

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Technology Process of 1,2-dihydro-4-(4-methylphenyl)-2-methyl-1-oxo-3-isoquinolinecarboxylic acid

There total 2 articles about 1,2-dihydro-4-(4-methylphenyl)-2-methyl-1-oxo-3-isoquinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 53904-41-9
4-(4-methylphenyl)-1-oxo-1H-isochromene-3-carboxylic acid

: 74-89-5
methylamine

: 912564-21-7
1,2-dihydro-4-(4-methylphenyl)-2-methyl-1-oxo-3-isoquinolinecarboxylic acid

Guidance literature:: 4-(4-methylphenyl)-1-oxo-1H-isochromene-3-carboxylic acid; methylamine; In ethanol; at 20 ℃; for 2h;

With sulfuric acid; In ethanol; for 3h; Heating;
DOI:10.1021/jm0603163

Reference yield:

: 85-55-2
2-(4-toluoyl)benzoic acid

: 912564-21-7
1,2-dihydro-4-(4-methylphenyl)-2-methyl-1-oxo-3-isoquinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 58 percent / K₂CO₃ / acetone; dimethylformamide / 20 °C

2.1: ethanol / 2 h / 20 °C

2.2: 86 percent / H₂SO₄ / ethanol / 3 h / Heating

With potassium carbonate; In ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm0603163