Methyl 5-broMo-2-Methyl-2H-indazole-3-carboxylate

Base Information

• Chemical Name: Methyl 5-broMo-2-Methyl-2H-indazole-3-carboxylate
• CAS No.: 1630906-74-9
• Molecular Formula: C₁₀H₉BrN₂O₂
• Molecular Weight: 269.098
• Mol file: 1630906-74-9.mol

Synonyms:Methyl 5-broMo-2-Methyl-2H-indazole-3-carboxylate;5-Bromo-2-methyl-2H-indazole-3-carboxylic acid methyl ester

Chemical Property of Methyl 5-broMo-2-Methyl-2H-indazole-3-carboxylate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Methyl 5-bromo-2-methyl-2H-indazole-3-carboxylate 97.0% ^*data from reagent suppliers

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Technology Process of Methyl 5-broMo-2-Methyl-2H-indazole-3-carboxylate

There total 3 articles about Methyl 5-broMo-2-Methyl-2H-indazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.4%

5-bromo-1H-indazole-3-carboxylic acid methyl ester (78155-74-5) + methyl iodide (74-88-4) → 5-bromo-1-methyl-1H-indazole-3-carboxylic acid methyl ester (1363381-41-2) + methyl 5-bromo-2-methyl-2H-indazole-3-carboxylate (1630906-74-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 17h; Cooling with ice;

Reference yield: 35.0%

5-bromo-1H-indazole-3-carboxylic acid methyl ester (78155-74-5) + methyl iodide (74-88-4) → methyl 5-bromo-2-methyl-2H-indazole-3-carboxylate (1630906-74-9) + methyl 5-bromo-2-isopropyl-2H-indazole-3-carboxylate

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

Reference yield:

methyl 1H-indazole-3-carboxylate (43120-28-1) → methyl 5-bromo-2-methyl-2H-indazole-3-carboxylate (1630906-74-9)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine / N,N-dimethyl-formamide / 41 h / 20 °C / Cooling with ice

2: potassium carbonate / N,N-dimethyl-formamide / 17 h / 20 °C / Cooling with ice

With bromine; potassium carbonate; In N,N-dimethyl-formamide;

upstream raw materials:

methyl 1H-indazole-3-carboxylate

5-bromo-1H-indazole-3-carboxylic acid methyl ester

methyl iodide

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