78155-74-5Relevant articles and documents
Heteroaromatic ring compound and application thereof
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Paragraph 0192; 0206-0209, (2021/07/08)
The invention relates to a heteroaromatic ring compound and application thereof. Specifically, the invention provides a compound shown as a formula I, or an optical isomer or raceme thereof, or a pharmaceutically acceptable salt thereof. The compound prov
INDAZOLE CONTAINING MACROCYCLES AND THERAPEUTIC USES THEREOF
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Paragraph 0361; 0363, (2020/01/08)
Indazole macrocycle compounds of formula (I) for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole macrocycle compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states. Formula (I)
Indazol-carboxamide-pyridinone derivatives as well as preparation method and applications thereof
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Paragraph 0071; 0072; 0073; 0074, (2018/03/26)
The invention belongs to the field of chemical medicine preparation, and concretely relates to indazol-carboxamide-pyridinone derivatives, a preparation method and applications thereof. The inventionprovides the indazol-carboxamide-pyridinone derivatives, and a structure is represented by a formula I. The present invention also provides the preparation method and the applications of the above indazol-carboxamide-pyridinone derivatives. The indazol-carboxamide-pyridinone derivatives provided by the invention are novel compounds obtained on the basis of a large number of screening, inhibit EZH2activity, and provide a novel selection for development and application of medicines for resisting tumors and autoimmune diseases.