ABBV-075

Base Information

Chemical Name:ABBV-075
CAS No.:1445993-26-9
Molecular Formula:C22H19F2N3O4S
Molecular Weight:459.473
Hs Code.:
Mol file:1445993-26-9.mol

Synonyms:N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide;ABBV-075;Mivebresib

Suppliers and Price of ABBV-075

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Mivebresib(ABBV-075） >98%
1 g
$ 2050.00

DC Chemicals
Mivebresib(ABBV-075） >98%
250 mg
$ 1100.00

DC Chemicals
Mivebresib(ABBV-075） >98%
100 mg
$ 600.00

Crysdot
Mivebresib 97%
25mg
$ 405.00

Crysdot
Mivebresib 97%
50mg
$ 728.00

ChemScene
Mivebresib 99.69%
100mg
$ 900.00

ChemScene
Mivebresib 99.69%
50mg
$ 540.00

ChemScene
Mivebresib 99.69%
10mg
$ 180.00

ChemScene
Mivebresib 99.69%
25mg
$ 300.00

ChemScene
Mivebresib 99.69%
5mg
$ 120.00

Total 25 raw suppliers

Chemical Property of ABBV-075

Chemical Property:

Boiling Point:608.9±65.0 °C(Predicted)
PKA:8.37±0.10(Predicted)
PSA：101.57000
Density:1.465±0.06 g/cm3(Predicted)
LogP:5.51950

Purity/Quality:

99%, ^*data from raw suppliers

Mivebresib(ABBV-075） >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ABBV-075

There total 17 articles about ABBV-075 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1445994-28-4
4-(5-amino-2-(2,4-difluorophenoxy)phenyl)-6-methyl-1H-pyrrolo[2,3-c]pyridine-7(6H)-one

: 594-44-5
Ethanesulfonyl chloride

: 1445993-26-9
N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide

Guidance literature:: 4-(5-amino-2-(2,4-difluorophenoxy)phenyl)-6-methyl-1H-pyrrolo[2,3-c]pyridine-7(6H)-one; Ethanesulfonyl chloride; With triethylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

With sodium hydroxide; In 1,4-dioxane; water; at 70 ℃; for 1h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b00746

Reference yield: 70.1%

: N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-1-tosyl-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide

: 1445993-26-9
N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide

Guidance literature:: N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-1-tosyl-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide; With cetyltrimethylammonim bromide; potassium hydroxide; In tetrahydrofuran; water; at 100 ℃; for 14h;

With hydrogenchloride; In water; ethyl acetate; pH=Ca.7;

Reference yield:

: 1445993-85-0
4-bromo-7-methoxy-1-(4-methylbenzenesulfonyl)pyrrolo[2,3-c]pyridine

: 1445993-26-9
N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / 1,4-dioxane / 16 h / 40 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Inert atmosphere

2.2: 3 h / 20 °C

3.1: potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 5 h / 80 °C / Inert atmosphere

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane / water; 1,4-dioxane / 2 h / 60 °C / Inert atmosphere

5.1: potassium hydroxide; cetyltrimethylammonim bromide / tetrahydrofuran; water / 14 h / 100 °C

5.2: pH Ca_.7

With hydrogenchloride; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; cetyltrimethylammonim bromide; sodium hydride; potassium hydroxide; XPhos; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;