4-(5-amino-2-(2,4-difluorophenoxy)phenyl)-6-methyl-1H-pyrrolo[2,3-c]pyridine-7(6H)-one

Base Information

Chemical Name:4-(5-amino-2-(2,4-difluorophenoxy)phenyl)-6-methyl-1H-pyrrolo[2,3-c]pyridine-7(6H)-one
CAS No.:1445994-28-4
Molecular Formula:C₂₀H₁₅F₂N₃O₂
Molecular Weight:367.355
Hs Code.:

Synonyms:4-(5-amino-2-(2,4-difluorophenoxy)phenyl)-6-methyl-1H-pyrrolo[2,3-c]pyridine-7(6H)-one

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Chemical Property of 4-(5-amino-2-(2,4-difluorophenoxy)phenyl)-6-methyl-1H-pyrrolo[2,3-c]pyridine-7(6H)-one

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Technology Process of 4-(5-amino-2-(2,4-difluorophenoxy)phenyl)-6-methyl-1H-pyrrolo[2,3-c]pyridine-7(6H)-one

There total 7 articles about 4-(5-amino-2-(2,4-difluorophenoxy)phenyl)-6-methyl-1H-pyrrolo[2,3-c]pyridine-7(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1445994-27-3
4-(2-(2,4-difluorophenoxy)-5-nitrophenyl)-6-methyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one

: 1445994-28-4
4-(5-amino-2-(2,4-difluorophenoxy)phenyl)-6-methyl-1H-pyrrolo[2,3-c]pyridine-7(6H)-one

Guidance literature:: With iron; ammonium chloride; In tetrahydrofuran; ethanol; water; for 2h; Reflux; Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b00746

Reference yield: 90.0%

: 367-27-1
2,4-difluorophenol

: 1445993-88-3
4-(2-fluoro-5-nitrophenyl)-6-methyl-1-tosyl-1H-pyrrolo[2,3-c]-pyridin-7(6H)-one

: 1445994-28-4
4-(5-amino-2-(2,4-difluorophenoxy)phenyl)-6-methyl-1H-pyrrolo[2,3-c]pyridine-7(6H)-one

Guidance literature:: 2,4-difluorophenol; 4-(2-fluoro-5-nitrophenyl)-6-methyl-1-tosyl-1H-pyrrolo[2,3-c]-pyridin-7(6H)-one; With potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 2h;

With iron; ammonium chloride; In methanol; water; at 80 ℃; for 1.5h;

Reference yield:

: 1445993-88-3
4-(2-fluoro-5-nitrophenyl)-6-methyl-1-tosyl-1H-pyrrolo[2,3-c]-pyridin-7(6H)-one

: 1445994-28-4
4-(5-amino-2-(2,4-difluorophenoxy)phenyl)-6-methyl-1H-pyrrolo[2,3-c]pyridine-7(6H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / dimethyl sulfoxide / 0.75 h / 110 °C / Inert atmosphere

2: iron; ammonium chloride / ethanol; water; tetrahydrofuran / 2 h / Reflux; Inert atmosphere

With iron; ammonium chloride; caesium carbonate; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide;
DOI:10.1021/acs.jmedchem.7b00746