Paroxol Methanesulfonate

Base Information

• Chemical Name: Paroxol Methanesulfonate
• CAS No.: 608521-21-7
• Molecular Formula: C14H20FNO3S
• Molecular Weight: 301.382
• Mol file: 608521-21-7.mol

Synonyms:Paroxol Methanesulfonate;(3S,4R)-4-(4-Fluorophenyl)-1-Methyl-3-piperidineMethanol Methanesulfonate

Chemical Property of Paroxol Methanesulfonate

Chemical Property:

• PSA: 54.99000
• LogP: 2.85590
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly, Sonicated), Ethyl Acetate (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

ParoxolMethanesulfonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Paroxol Methanesulfonate

There total 2 articles about Paroxol Methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methanesulfonyl chloride (124-63-0) + (3S,4R)-trans-4-(4-fluorophenyl)-3-hydroxymethyl-N-methylpiperidine (105812-81-5) → ((3S,4R)-4-(4-fluorophenyl)-1-methylpiperidin-3-yl)methyl methanesulfonate (608521-21-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

N,N-dimethyl-ethanamine (598-56-1) + methanesulfonyl chloride (124-63-0) + (3S,4R)-trans-4-(4-fluorophenyl)-3-hydroxymethyl-N-methylpiperidine (105812-81-5) → ((3S,4R)-4-(4-fluorophenyl)-1-methylpiperidin-3-yl)methyl methanesulfonate (608521-21-7)

Guidance literature:

With ammonium hydroxide; In dichloromethane;

Reference yield: 50.0%

benzo[d][1,3]dioxol-(2,2-d2)-5-ol (923932-05-2) + ((3S,4R)-4-(4-fluorophenyl)-1-methylpiperidin-3-yl)methyl methanesulfonate (608521-21-7) → (3S,4R)-3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidine (936838-88-9)

Guidance literature:

With sodium methylate; In N,N-dimethyl-formamide; for 0.25h; Heating / reflux;

upstream raw materials:

N,N-dimethyl-ethanamine

methanesulfonyl chloride

(3S,4R)-trans-4-(4-fluorophenyl)-3-hydroxymethyl-N-methylpiperidine

Downstream raw materials:

(3S,4R)-3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 608521-21-7 Paroxol Methanesulfonate

Send

Send

Metric Ton KG G Pound L ML

Send

Send