2',3'-Isopropylidene Ribavirin

Base Information

• Chemical Name: 2',3'-Isopropylidene Ribavirin
• CAS No.: 52663-90-8
• Molecular Formula: C11H16N4O5
• Molecular Weight: 284.272
• Mol file: 52663-90-8.mol

Synonyms:2',3'-Isopropylidene Ribavirin;1-[2,3-O-(1-Methylethylidene)-β-D-ribofuranosyl]-1H-1,2,4-triazole-3-carboxaMide;1-(2,3-O-Isopropyliden-beta-D-ribofuranosyl)-1H-1,2,4-triazol-3-carboxaMid

Chemical Property of 2',3'-Isopropylidene Ribavirin

Chemical Property:

• PSA: 121.72000
• LogP: -0.51290
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

2’,3’-IsopropylideneRibavirin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Protected Ribavirin.

Technology Process of 2',3'-Isopropylidene Ribavirin

There total 7 articles about 2',3'-Isopropylidene Ribavirin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,2-dimethoxy-propane (77-76-9) + ribavirin (36791-04-5,66510-90-5) → 1-(2',3'-di-O-isopropylidene-β-D-ribofuranosyl)<1,2,4>triazole-3-carboxamide (52663-90-8)

Guidance literature:

With toluene-4-sulfonic acid; In acetone; at 60 ℃; for 3h; Concentration; Temperature;

Reference yield: 86.0%

1-(2,3-O-Isopropyliden-β-D-ribofuranosyl)-1H-1,2,4-triazol-3-carbonsaeure-ethylester (79437-74-4) → 1-(2',3'-di-O-isopropylidene-β-D-ribofuranosyl)<1,2,4>triazole-3-carboxamide (52663-90-8)

Guidance literature:

With ammonia; In methanol; Ambient temperature;

DOI:10.1002/cber.19811140814

Reference yield: 85.91%

2,2-dimethoxy-propane (77-76-9) + acetone (67-64-1) + ribavirin (36791-04-5,66510-90-5) → 1-(2',3'-di-O-isopropylidene-β-D-ribofuranosyl)<1,2,4>triazole-3-carboxamide (52663-90-8)

Guidance literature:

With toluene-4-sulfonic acid; at 70 ℃; for 0.5h;

upstream raw materials:

1-(2,3-O-Isopropyliden-β-D-ribofuranosyl)-1H-1,2,4-triazol-3-carbonsaeure-ethylester

2,2-dimethoxy-propane

ribavirin

acetone

Downstream raw materials:

1-[5,5-(N,N'-diphenyl-N,N'-ethane-1,2-diyl-diamino)-O²,O³-isopropylidene-β-D-5-deoxy-ribofuranosyl]-1H-[1,2,4]triazole-3-carboxylic acid amide

ribavirin

1-(5'-O-sulfamoyl-β-D-ribofuranosyl)<1,2,4>triazole-3-carboxamide

phosphoric acid ((3aR,4R,6R,6aR)-6-(3-carbamoyl-[1,2,4]-triazol-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl) ester 2-{[5-cyclopropyl-2-(4-fluorophenyl)-3-methylcarbamoylbenzofuran-6-yl]methanesulfonylamino}ethyl ester

Refernces

• 1、 -. "MODULATION OF IMMUNE CELLS". Paragraph 0049; 00132-00133. . Retrieved 2021/08/06.
• 2、 -. "Oligomer conjugates of heteropentacyclic nucleosides". Page/Page column 30; 31; 32. . Retrieved 2015/12/09.