6-chloro-5-iodo-2-(Methylsulfonyl)-1H-benziMidazole

Base Information

• Chemical Name: 6-chloro-5-iodo-2-(Methylsulfonyl)-1H-benziMidazole
• CAS No.: 1219741-19-1
• Molecular Formula: C8H6ClIN2O2S
• Molecular Weight: 356.571
• Hs Code.: 2933990090
• Mol file: 1219741-19-1.mol

Synonyms:6-chloro-5-iodo-2-(Methylsulfonyl)-1H-benziMidazole;6-Chloro-5-iodo-2-(Methylsulfonyl)-1H-benzo[d]iMidazole;5-Chloro-6-iodo-2-(Methylsulfonyl)-1H-benzo[d]iMidazole

Chemical Property of 6-chloro-5-iodo-2-(Methylsulfonyl)-1H-benziMidazole

Chemical Property:

• PSA: 71.20000
• LogP: 3.30520
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

5-Chloro-6-iodo-2-(methylsulfonyl)-1H-benzo[d]imidazole 97+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-chloro-5-iodo-2-(Methylsulfonyl)-1H-benziMidazole

There total 6 articles about 6-chloro-5-iodo-2-(Methylsulfonyl)-1H-benziMidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

6-chloro-5-iodo-2-(methylthio)-1H-benzimidazole (1219741-22-6) → 6-chloro-5-iodo-2-(methylsulfonyl)-1H-benzo[d]imidazole (1219741-19-1)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 0.166667h;

DOI:10.1021/acs.jmedchem.7b01344

Reference yield:

5-chloro-2-nitroaniline (1635-61-6) → 6-chloro-5-iodo-2-(methylsulfonyl)-1H-benzo[d]imidazole (1219741-19-1)

Guidance literature:

Multi-step reaction with 5 steps

1: acetic acid; N-iodo-succinimide / 50 °C

2: ammonium chloride; iron / ethanol; water / 50 °C / Inert atmosphere

3: potassium hydroxide / ethanol / 3 h / Reflux

4: potassium carbonate / acetone / 0 - 20 °C

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 20 °C

With N-iodo-succinimide; iron; potassium carbonate; ammonium chloride; acetic acid; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; In ethanol; dichloromethane; water; acetone;

Reference yield:

2-nitro-4-iodo-5-chloroaniline (335349-57-0) → 6-chloro-5-iodo-2-(methylsulfonyl)-1H-benzo[d]imidazole (1219741-19-1)

Guidance literature:

Multi-step reaction with 4 steps

1: ammonium chloride; iron / ethanol; water / 50 °C / Inert atmosphere

2: potassium hydroxide / ethanol / 3 h / Reflux

3: potassium carbonate / acetone / 0 - 20 °C

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 20 °C

With iron; potassium carbonate; ammonium chloride; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; In ethanol; dichloromethane; water; acetone;

upstream raw materials:

6-chloro-5-iodo-2-(methylthio)-1H-benzimidazole

5-chloro-2-nitroaniline

2-nitro-4-iodo-5-chloroaniline

2, 4-chloro-5-iodobenzene-1,2-diamine

Downstream raw materials:

5-biphenyl-4-yl-6-chloro-2-(methylsulfonyl)-1H-benzimidazole

6-chloro-2-methanesulfonyl-5-phenylethynyl-1H-benzoimidazole

1-biphenyl-4-ylmethyl-6-chloro-5-iodo-2-methanesulfonyl-1H-benzimidazole

1-benzyl-6-chloro-5-iodo-2-methanesulfonyl-1H-benzimidazole