2-(3-Fluoro-2-nitrophenyl)acetic acid

Base Information

• Chemical Name: 2-(3-Fluoro-2-nitrophenyl)acetic acid
• CAS No.: 872141-25-8
• Molecular Formula: C8H6FNO4
• Molecular Weight: 199.138
• Hs Code.: 2916399090
• Mol file: 872141-25-8.mol

Synonyms:2-(3-Fluoro-2-nitrophenyl)acetic acid;3-Fluoro-2-nitrobenzeneacetic acid;2-(3-Fluoro-2-nitrophenyl)

Chemical Property of 2-(3-Fluoro-2-nitrophenyl)acetic acid

Chemical Property:

• PSA: 83.12000
• LogP: 1.88420
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98.5% ^*data from raw suppliers

(3-Fluoro-2-nitrophenyl)aceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (3-Fluoro-2-nitrophenyl)acetic acid

Technology Process of 2-(3-Fluoro-2-nitrophenyl)acetic acid

There total 2 articles about 2-(3-Fluoro-2-nitrophenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(3-fluoro-2-nitrophenyl)malonic acid dimethyl ester (872141-24-7) → 2-(3-fluoro-2-nitrophenyl)acetic acid (872141-25-8)

Guidance literature:

With hydrogenchloride; water; for 5h; Heating / reflux;

Reference yield:

2,6-difluoro-1-nitrobenzene (19064-24-5) → 2-(3-fluoro-2-nitrophenyl)acetic acid (872141-25-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 65 °C

2: hydrogenchloride / water / 5 h / Reflux

With hydrogenchloride; potassium carbonate; In water; N,N-dimethyl-formamide;

Reference yield: 98.0%

methanol (67-56-1) + 2-(3-fluoro-2-nitrophenyl)acetic acid (872141-25-8) → methyl 2-(3-fluoro-2-nitrophenyl)acetate

Guidance literature:

With sulfuric acid; at 65 ℃; Inert atmosphere;

DOI:10.1055/s-0040-1707250

upstream raw materials:

2-(3-fluoro-2-nitrophenyl)malonic acid dimethyl ester

2,6-difluoro-1-nitrobenzene

Downstream raw materials:

7-fluoro-1,3-dihydro-indol-2-one

N-(1-benzyl-piperidin-4-yl)-2-(3-fluoro-2-nitrophenyl)-acetamide

(1-benzyl-piperidin-4-yl)-[2-(3-fluoro-2-nitro-phenyl)-ethyl]-amine

[2-(2-amino-3-fluorophenyl)-ethyl]-(1-benzyl-piperidin-4-yl)-amine

Refernces

• 1、 Fensome, Andrew,Adams, William R.,Adams, Andrea L.,Berrodin, Tom J.,Cohen, Jeff,Huselton, Christine,Illenberger, Arthur,Kern, Jeffrey C.,Hudak, Valerie A.,Marella, Michael A.,Melenski, Edward G.,McComas, Casey C.,Mugford, Cheryl A.,Slayden, Ov D.,Yudt, Matthew,Zhang, Zhiming,Zhang, Puwen,Zhu, Yuan,Winneker, Richard C.,Wrobel, Jay E.. "Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)- 1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348)". . p. 1861 - 1873. Retrieved 2008/12/20.
• 2、 -. "Progesterone receptor antagonists, contraceptive regimens, and kits". Page/Page column 9. . Retrieved 2010/02/15.