Isomannide dinitrate

Base Information

• Chemical Name: Isomannide dinitrate
• CAS No.: 551-43-9
• Molecular Formula: C6H8N2O8
• Molecular Weight: 236.1363
• Hs Code.: 2932999099
• DSSTox Substance ID: DTXSID801315109
• Mol file: 551-43-9.mol

Synonyms:isomannide dinitrate

Chemical Property of Isomannide dinitrate

Chemical Property:

• Vapor Pressure: 3.19E-05mmHg at 25°C
• Melting Point: 50-51 °C
• Boiling Point: 365.9°Cat760mmHg
• Flash Point: 186.6°C
• PSA: 128.56000
• Density: 1.65g/cm³
• LogP: -0.01580
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform, Ethyl Acetate (Slightly)
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 2
• Exact Mass: 236.02806522
• Heavy Atom Count: 16
• Complexity: 268

Purity/Quality:

99% ^*data from raw suppliers

IsomannideDinitrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(C2C(O1)C(CO2)O[N+](=O)[O-])O[N+](=O)[O-]
• Isomeric SMILES: C1[C@H]([C@@H]2[C@H](O1)[C@@H](CO2)O[N+](=O)[O-])O[N+](=O)[O-]
• Uses: Isomannide Dinitrate is an active vasodepressor agent. When administered orally to hypertensive rat causes a decline in blood pressure. It is also a urinary metabolite. A vasodilator

Technology Process of Isomannide dinitrate

There total 3 articles about Isomannide dinitrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,6-dichloro-2S,3S,4S,5S-hexanetetraol (7251-85-6,58073-31-7) → isomannide dinitrate (551-43-9)

Guidance literature:

With silver nitrate; acetonitrile;

DOI:10.1021/ja01530a043

Reference yield:

1,4:3,6-dianhydro-D-mannitol (641-74-7) → isomannide dinitrate (551-43-9)

Guidance literature:

With sulfuric acid; nitric acid;

Reference yield:

→ isomannide dinitrate (551-43-9)

Guidance literature:

Aus Isomannit beim Behandeln mit rauchender Salpetersaeure u. einem Acetanhydrid-Essigsaeure-Gemisch bei 0grad;

DOI:10.1139/v60-071

upstream raw materials:

1,6-dichloro-2S,3S,4S,5S-hexanetetraol

1,4:3,6-dianhydro-D-mannitol