7-Boc-7-azaspiro[3.5]nona...

Base Information

• Chemical Name: 7-Boc-7-azaspiro[3.5]nona...
• CAS No.: 1346556-73-7
• Molecular Formula: C14H23NO3
• Molecular Weight: 253.342
• Hs Code.: 2933990090
• Mol file: 1346556-73-7.mol

Synonyms:7-Boc-7-azaspiro[3.5]nonane-2-carbaldehyde;tert-butyl 2-formyl-7-azaspiro[3.5]nonane-7-carboxylate

Chemical Property of 7-Boc-7-azaspiro[3.5]nona...

Chemical Property:

• Boiling Point: 353.1±42.0 °C(Predicted)
• PKA: -1.04±0.40(Predicted)
• PSA: 46.61000
• Density: 1.09±0.1 g/cm3(Predicted)
• LogP: 2.55050

Purity/Quality:

99%, ^*data from raw suppliers

7-Boc-7-azaspiro[3.5]nonane-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Boc-7-azaspiro[3.5]nona...

There total 4 articles about 7-Boc-7-azaspiro[3.5]nona... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl 2-(methoxymethylidene)-7-azaspiro[3.5]nonane-7-carboxylate → tert-butyl 2-formyl-7-azaspiro[3.5]nonane-7-carboxylate (1346556-73-7)

Guidance literature:

With trifluoroacetic acid; In water; acetonitrile; at 20 ℃; for 2h;

Reference yield: 92.0%

C21H36BNO2 → tert-butyl 2-formyl-7-azaspiro[3.5]nonane-7-carboxylate (1346556-73-7)

Guidance literature:

With Dess-Martin periodane; In dichloromethane;

DOI:10.1016/j.bmcl.2011.08.055

Reference yield:

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate (203661-69-2) → tert-butyl 2-formyl-7-azaspiro[3.5]nonane-7-carboxylate (1346556-73-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / toluene / 0.33 h / 20 °C / Inert atmosphere

1.2: 4 h / 70 °C / Inert atmosphere

2.1: trifluoroacetic acid / acetonitrile; water / 1 h / 20 °C

With potassium tert-butylate; trifluoroacetic acid; In water; toluene; acetonitrile; 1.1: |Wittig Olefination / 1.2: |Wittig Olefination;

DOI:10.1016/j.bmc.2018.02.032

upstream raw materials:

tert-butyl 2-methylene-7-azaspiro[3.5]nonane-7-carboxylate

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate

Downstream raw materials:

C₂₇H₃₁F₃N₂O₃

C₂₇H₂₈F₃N₅O₂

C₂₇H₃₃F₃N₂O₃

tert-butyl 2-{3-[4-(methanesulfonyl)phenoxy]propyl}-7-azaspiro[3.5]nonane-7-carboxylate

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