5-BroMo-6-Methylnicotinicacid

Base Information

• Chemical Name: 5-BroMo-6-Methylnicotinicacid
• CAS No.: 1190862-72-6
• Molecular Formula: C7H6BrNO2
• Molecular Weight: 216.034
• Hs Code.: 2933399090
• Mol file: 1190862-72-6.mol

Synonyms:5-BroMo-6-Methylnicotinicacid;3-Pyridinecarboxylic acid, 5-broMo-6-Methyl;5-Bromo-6-methyl-3-pyridinecarboxylic acid;5-Bromo-6-methylpyridin-3-carboxylic acid

Chemical Property of 5-BroMo-6-Methylnicotinicacid

Chemical Property:

• Boiling Point: 333.0±42.0 °C(Predicted)
• PKA: 3.25±0.10(Predicted)
• PSA: 50.19000
• Density: 1.692±0.06 g/cm3(Predicted)
• LogP: 1.85070
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-6-methylnicotinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BroMo-6-Methylnicotinicacid

There total 1 articles about 5-BroMo-6-Methylnicotinicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

ethyl 5-bromo-6-methylnicotinate (1190862-70-4) → 5-bromo-6-methylnicotinic acid (1190862-72-6)

Guidance literature:

ethyl 5-bromo-6-methylpyridin-3-carboxylate; With water; sodium hydroxide; In ethanol; at 20 ℃; for 3h;

With hydrogenchloride; In ethanol; water; pH=4 - 5;

Reference yield: 65.0%

4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline (694499-26-8) + 5-bromo-6-methylnicotinic acid (1190862-72-6) → 5-bromo-6-methyl-N-[4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylphenyl]nicotinamide

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; Cooling with ice;

Reference yield:

5-bromo-6-methylnicotinic acid (1190862-72-6) → 5-amino-3-bromo-2-methylpyridine (186593-43-1)

Guidance literature:

5-bromo-6-methylnicotinic acid; With diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide; tert-butyl alcohol; at 100 ℃; for 2h;

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 2h;

upstream raw materials:

ethyl 5-bromo-6-methylnicotinate

Downstream raw materials:

5-amino-3-bromo-2-methylpyridine

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