ethyl 5-broMo-6-Methylnicotinate

Base Information

• Chemical Name: ethyl 5-broMo-6-Methylnicotinate
• CAS No.: 1190862-70-4
• Molecular Formula: C₉H₁₀BrNO₂
• Molecular Weight: 244.088
• Hs Code.: 2933399090
• Mol file: 1190862-70-4.mol

Synonyms:ethyl 5-broMo-6-Methylnicotinate;3-Pyridinecarboxylic acid, 5-broMo-6-Methyl-, ethyl ester;5-BroMo-6-Methyl-nicotinic acid ethyl ester;5-Bromo-6-methyl-3-pyridinecarboxylic acid ethyl ester

Chemical Property of ethyl 5-broMo-6-Methylnicotinate

Chemical Property:

• Boiling Point: 270.5±35.0 °C(Predicted)
• PKA: 1.66±0.20(Predicted)
• PSA: 39.19000
• Density: 1.439±0.06 g/cm3(Predicted)
• LogP: 2.32920
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

Ethyl5-Bromo-6-methylnicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 5-broMo-6-Methylnicotinate

There total 1 articles about ethyl 5-broMo-6-Methylnicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

dihydroxy-methyl-borane (13061-96-6) + ethyl 5,6-dibromonicotinate (1190862-68-0) → ethyl 5-bromo-6-methylnicotinate (1190862-70-4)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 110 ℃; for 72h; Inert atmosphere;

Reference yield: 65.0%

ethyl 5-bromo-6-methylnicotinate (1190862-70-4) + bis(pinacol)diborane (73183-34-3) → ethyl 6-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 60 ℃;

Reference yield: 43.0%

ethyl 5-bromo-6-methylnicotinate (1190862-70-4) → 5-bromo-6-methylnicotinic acid (1190862-72-6)

Guidance literature:

ethyl 5-bromo-6-methylpyridin-3-carboxylate; With water; sodium hydroxide; In ethanol; at 20 ℃; for 3h;

With hydrogenchloride; In ethanol; water; pH=4 - 5;

upstream raw materials:

dihydroxy-methyl-borane

ethyl 5,6-dibromonicotinate

Downstream raw materials:

5-bromo-6-methylnicotinic acid

Refernces