3-fluoro-2-hydroxy-5-nitrobenzaldehyde

Base Information

• Chemical Name: 3-fluoro-2-hydroxy-5-nitrobenzaldehyde
• CAS No.: 2923-99-1
• Molecular Formula: C7H4FNO4
• Molecular Weight: 185.111
• Mol file: 2923-99-1.mol

Synonyms:3-fluoro-2-hydroxy-5-nitrobenzaldehyde

Chemical Property of 3-fluoro-2-hydroxy-5-nitrobenzaldehyde

Chemical Property:

• PSA: 83.12000
• LogP: 1.77520

Purity/Quality:

95% ^*data from raw suppliers

3-Fluoro-2-hydroxy-5-nitrobenzaldehyde 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-fluoro-2-hydroxy-5-nitrobenzaldehyde

There total 1 articles about 3-fluoro-2-hydroxy-5-nitrobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-fluorosalicylaldehyde (394-50-3) → 3-fluoro-2-hydroxy-5-nitrobenzaldehyde (2923-99-1)

Guidance literature:

With nitric acid; In acetic acid; at 0 ℃; for 1h;

Reference yield:

1.3-propanedithiol (109-80-8) + 3-fluoro-2-hydroxy-5-nitrobenzaldehyde (2923-99-1) + p-methoxybenzyl chloride (824-94-2) → 2-(3-fluoro-2-(4-methoxybenzyloxy)-5-nitrophenyl)-1,3-dithiane

Guidance literature:

1.3-propanedithiol; 3-fluoro-2-hydroxy-5-nitrobenzaldehyde; With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃;

p-methoxybenzyl chloride; With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 3h;

Reference yield:

3-fluoro-2-hydroxy-5-nitrobenzaldehyde (2923-99-1) → benzyl 2-(2,2-difluoroethyloxy)-3-fluoro-5-nitrobenzyl(methyl)carbamate

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanol; ethanol / 1 h / 20 °C

1.2: 3 h / 0 - 20 °C

1.3: 16 h / 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 50 - 100 °C

With caesium carbonate; In methanol; ethanol; N,N-dimethyl-formamide;

upstream raw materials:

3-fluorosalicylaldehyde

Refernces

• 1、 Glunz, Peter W.,Mueller, Luciano,Cheney, Daniel L.,Ladziata, Vladimir,Zou, Yan,Wurtz, Nicholas R.,Wei, Anzhi,Wong, Pancras C.,Wexler, Ruth R.,Priestley, E. Scott. "Atropisomer Control in Macrocyclic Factor VIIa Inhibitors". supporting information. p. 4007 - 4018. Retrieved 2016/05/19.
• 2、 -. "MACROCYCLIC FACTOR VIIA INHIBITORS". Paragraph 00277; 00278. . Retrieved 2014/01/08.