FMoc-α-Me-Phe(2,6-DiF)-OH

Base Information

Chemical Name:FMoc-α-Me-Phe(2,6-DiF)-OH
CAS No.:1223105-51-8
Molecular Formula:C25H21F2NO4
Molecular Weight:437.443
Hs Code.:
Mol file:1223105-51-8.mol

Synonyms:FMoc-α-Me-Phe(2,6-DiF)-OH;Fmoc-alpha-Me-L-Phe(2,6-F2)-OH;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2,6-difluorophenyl)-2-methylpropanoic acid

Suppliers and Price of FMoc-α-Me-Phe(2,6-DiF)-OH

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2,6-difluorophenyl)-2-methylpropanoicAcid
100mg
$ 220.00

Crysdot
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2,6-difluorophenyl)-2-methylpropanoicacid 95+%
1g
$ 650.00

Crysdot
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2,6-difluorophenyl)-2-methylpropanoicacid 95+%
250mg
$ 205.00

Crysdot
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2,6-difluorophenyl)-2-methylpropanoicacid 95+%
100mg
$ 88.00

ChemSupplyAustralia
(S)-N-Fmoc-α-Methyl-2,6-difluorophenylalanine, 98%
100 mg
$ 74.80

ChemSupplyAustralia
(S)-N-Fmoc-α-Methyl-2,6-difluorophenylalanine, 98%
1 g
$ 440.00

ChemSupplyAustralia
(S)-N-Fmoc-α-Methyl-2,6-difluorophenylalanine, 98%
5 g
$ 1320.00

ChemPep
Fmoc-α-Me-Phe(2,6-DiF)-OH
5g
$ 1400.00

ChemPep
Fmoc-α-Me-Phe(2,6-DiF)-OH
1g
$ 500.00

Chemenu
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2,6-difluorophenyl)-2-methylpropanoicacid 95%
1g
$ 608.00

Total 17 raw suppliers

Chemical Property of FMoc-α-Me-Phe(2,6-DiF)-OH

Chemical Property:

PSA：75.63000
LogP:5.28020
Storage Temp.:Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2,6-difluorophenyl)-2-methylpropanoicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/38
Safety Statements: 26

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of FMoc-α-Me-Phe(2,6-DiF)-OH

There total 1 articles about FMoc-α-Me-Phe(2,6-DiF)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2,6-difluoro-α-methylphenylalanine hydrochloride

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 1223105-51-8
N-Fmoc-(S)-2,6-difluoro-α-methylphenylalanine

Guidance literature:: With sodium hydrogencarbonate; In water; for 72h; pH=7 - 8;
DOI:10.1021/jm900752a

Reference yield: 31.0%

: 872142-89-7
(S)-2-(((9H-fluoren-9-yl)methoxy)carbonyl-amino)-3-(2'-ethyl-4'-methoxybi-phenyl-4-yl)propanoic acid

: 1223105-51-8
N-Fmoc-(S)-2,6-difluoro-α-methylphenylalanine

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(2'-methyl-[1,1'-biphenyl]-4-yl)propanoic acid

: C₄₀H₃₃N₃O₄S

: 71989-33-8
Fmoc-Ser(tBu)-OH

: 71989-14-5
Fmoc-(tBu)Asp-OH

: 71989-18-9
Fmoc-Glu(OtBu)-OH

: 71989-35-0,138797-71-4
Fmoc-Thr(tBu)-OH

: 94744-50-0
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-α-aminoisobutyric acid

: 516521-28-1
His-[2-amino-iso-butyryl]-Glu-Gly-Thr-[(L)-α-methyl-(2,6-difluorophenyl)alanyl]-Thr-Ser-Asp-[2-amino-3-(2'-ethyl-4'-methoxy-biphenyl-4-yl)propanoyl]-[2-amino-3-(2'-methyl-biphenyl-4-yl)propanoyl]-NH2

Guidance literature:: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(2'-methyl-[1,1'-biphenyl]-4-yl)propanoic acid; With 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;

With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

(S)-2-(((9H-fluoren-9-yl)methoxy)carbonyl-amino)-3-(2'-ethyl-4'-methoxybi-phenyl-4-yl)propanoic acid; N-Fmoc-(S)-2,6-difluoro-α-methylphenylalanine; N-(fluoren-9-ylmethoxycarbonyl)glycine; C₄₀H₃₃N₃O₄S; Fmoc-Ser(tBu)-OH; Fmoc-(tBu)Asp-OH; Fmoc-Glu(OtBu)-OH; Fmoc-Thr(tBu)-OH; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-α-aminoisobutyric acid; Further stages;
DOI:10.1021/acs.jmedchem.5b00166

Reference yield:

: 1223105-51-8
N-Fmoc-(S)-2,6-difluoro-α-methylphenylalanine

: (S)-2-((9H-fluoren-9-yloxy)carbonylamino)-3-(2'-ethyl-4'-methoxy-biphenyl-4-yl)propanoic acid

: C₃₄H₃₆N₃O₅Pol

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 71989-33-8
Fmoc-Ser(tBu)-OH

: 71989-14-5
Fmoc-(tBu)Asp-OH

: 71989-18-9
Fmoc-Glu(OtBu)-OH

: 71989-35-0,138797-71-4
Fmoc-Thr(tBu)-OH

: 109425-51-6
Fmoc-His(Trt)-OH

: 94744-50-0
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-α-aminoisobutyric acid

: 516521-28-1
His-[2-amino-iso-butyryl]-Glu-Gly-Thr-[(L)-α-methyl-(2,6-difluorophenyl)alanyl]-Thr-Ser-Asp-[2-amino-3-(2'-ethyl-4'-methoxy-biphenyl-4-yl)propanoyl]-[2-amino-3-(2'-methyl-biphenyl-4-yl)propanoyl]-NH2

Guidance literature:: (S)-2-((9H-fluoren-9-yloxy)carbonylamino)-3-(2'-ethyl-4'-methoxy-biphenyl-4-yl)propanoic acid; C₃₄H₃₆N₃O₅Pol; With 1-hydroxy-7-aza-benzotriazole; dicyclohexyl-carbodiimide; In 1-methyl-pyrrolidin-2-one; Automated synthesizer; solid phase reaction;

With piperidine; In N,N-dimethyl-formamide; for 0.35h; Automated synthesizer; solid phase reaction;

N-Fmoc-(S)-2,6-difluoro-α-methylphenylalanine; N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Ser(tBu)-OH; Fmoc-(tBu)Asp-OH; Fmoc-Glu(OtBu)-OH; Fmoc-Thr(tBu)-OH; Fmoc-His(Trt)-OH; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-α-aminoisobutyric acid; Further stages;
DOI:10.1021/jm900752a