3-(Pyridin-3-yloxy)propan-1-amine

Base Information

• Chemical Name: 3-(Pyridin-3-yloxy)propan-1-amine
• CAS No.: 112086-55-2
• Molecular Formula: C8H12N2O
• Molecular Weight: 152.19
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID20436847
• Wikidata: Q82252184
• Mol file: 112086-55-2.mol

Synonyms:3-(PYRIDIN-3-YLOXY)PROPAN-1-AMINE;112086-55-2;3-pyridin-3-yloxypropan-1-amine;3-(3-Pyridyloxy)propylamine;CHEMBRDG-BB 4004844;3-(3-Pyridinyloxy)-1-propanamine;3-(3-pyridinyloxy)proPanamine;SCHEMBL4805267;3-(pyridin-3-yloxy)propylamine;DTXSID20436847;YMKBFDMRGWLFIS-UHFFFAOYSA-N;MFCD08059775;AKOS009559468;3-(3-aminopropoxy)pyridine, AldrichCPR;CS-0269381;FT-0706843;EN300-1858078

Chemical Property of 3-(Pyridin-3-yloxy)propan-1-amine

Chemical Property:

• Vapor Pressure: 0.004mmHg at 25°C
• Boiling Point: 280.035°C at 760 mmHg
• Flash Point: 123.161°C
• PSA: 48.14000
• Density: 1.062g/cm³
• LogP: 1.50950
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 152.094963011
• Heavy Atom Count: 11
• Complexity: 98.1

Purity/Quality:

98%min ^*data from raw suppliers

3-(Pyridin-3-yloxy)propan-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CN=C1)OCCCN

Technology Process of 3-(Pyridin-3-yloxy)propan-1-amine

There total 4 articles about 3-(Pyridin-3-yloxy)propan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-<3-(3-pyridinyloxy)propyl>-1H-isoindole-1,3(2H)-dione (122213-99-4) → 3-(pyridin-3-yloxy)-1-propylamine (112086-55-2)

Guidance literature:

With hydrazine hydrate; In ethanol; Ambient temperature;

DOI:10.1021/jm00128a026

Reference yield:

ammonium hydroxide (1336-21-6) + 3-chloro-1-(pyridin-3-yloxy)propane (184419-48-5) → 3-(pyridin-3-yloxy)-1-propylamine (112086-55-2)

Guidance literature:

With sodium chloride; In methanol;

Reference yield:

3-HYDROXYPYRIDINE (109-00-2) → 3-(pyridin-3-yloxy)-1-propylamine (112086-55-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 43.3 percent / Ph₃P, diethyl azidocarboxylate / dimethylformamide / Ambient temperature

2: 80 percent / 40percent aq. N₂H₄ / ethanol / Ambient temperature

With hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00128a026

upstream raw materials:

2-<3-(3-pyridinyloxy)propyl>-1H-isoindole-1,3(2H)-dione

3-HYDROXYPYRIDINE

ammonium hydroxide

3-chloro-1-(pyridin-3-yloxy)propane