2,5-Diazaspiro[3.4]octane-5-carboxylic acid, 1-oxo-, phenylMethyl ester

Base Information

• Chemical Name: 2,5-Diazaspiro[3.4]octane-5-carboxylic acid, 1-oxo-, phenylMethyl ester
• CAS No.: 914389-34-7
• Molecular Formula: C14H16N2O3
• Molecular Weight: 260.293
• Mol file: 914389-34-7.mol

Synonyms:2,5-Diazaspiro[3.4]octane-5-carboxylic acid, 1-oxo-, phenylMethyl ester;Benzyl 1-Oxo-2,5-Diazaspiro[3.4]Octane-5-Carboxylate

Chemical Property of 2,5-Diazaspiro[3.4]octane-5-carboxylic acid, 1-oxo-, phenylMethyl ester

Chemical Property:

• Vapor Pressure: 6.16E-10mmHg at 25°C
• Boiling Point: 495°C at 760 mmHg
• Flash Point: 253.1°C
• PSA: 62.13000
• Density: 1.3g/cm³
• LogP: 1.50140

Purity/Quality:

97% ^*data from raw suppliers

Benzyl1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-Diazaspiro[3.4]octane-5-carboxylic acid, 1-oxo-, phenylMethyl ester

There total 7 articles about 2,5-Diazaspiro[3.4]octane-5-carboxylic acid, 1-oxo-, phenylMethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(+/-)-5-benzyloxycarbonyl-2-(4-methoxyphenyl)-2,5-diazaspiro[3,4]octan-1-one (914389-32-5) → benzyl 2-(4-methoxybenzyl)-1-oxo-2,5-diazaspiro[3.4]-octane-5-carboxylate (914389-34-7)

Guidance literature:

With ammonium cerium(IV) nitrate; In acetonitrile; at 0 ℃;

DOI:10.1021/jo061189l

Reference yield: 48.6%

benzyl 2-(4-methoxybenzyl)-1-oxo-2,5-diazaspiro[3.4]-octane-5-carboxylate → benzyl 2-(4-methoxybenzyl)-1-oxo-2,5-diazaspiro[3.4]-octane-5-carboxylate (914389-34-7)

Guidance literature:

With ammonium cerium (IV) nitrate; In water; acetonitrile; at 0 ℃; for 1h;

Reference yield:

(S)-benzyloxycarbonyl-proline acid chloride (61350-60-5,61350-62-7,89705-40-8,106709-50-6) → benzyl 2-(4-methoxybenzyl)-1-oxo-2,5-diazaspiro[3.4]-octane-5-carboxylate (914389-34-7)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 0.75 h / -40 °C

2: BF₃*Et₂O / CH₂Cl₂ / 12 h / -40 - 20 °C

3: 71 percent / aq. CAN / acetonitrile / 0 °C

With ammonium cerium(IV) nitrate; boron trifluoride diethyl etherate; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1021/jo061189l

upstream raw materials:

(+/-)-5-benzyloxycarbonyl-2-(4-methoxyphenyl)-2,5-diazaspiro[3,4]octan-1-one

(S)-benzyloxycarbonyl-proline acid chloride

L-proline

benzyl chloroformate

Downstream raw materials:

benzyl 2-(2-((2-((tert-butyldimethylsilyl)oxy)-1-(pyrimidin-2-yl)propyl)amino)-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

2-(5-((benzyloxy)carbonyl)-1-oxo-2,5-diazaspiro[3.4]octan-2-yl)acetic acid

(2R,3S)-4-amino-3-(2-(5-(1-(cyclohexylmethyl)-5-methyl-1H-1,2,3-triazole-4-carbonyl)-1-oxo-2,5-diazaspiro[3.4]octan-2-yl)acetamido)-4-oxobutan-2-yl acetate

benzyl 2-(2-(((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)amino)-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

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