914389-32-5

Basic information

• Product Name: benzyl 2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate
• CAS NO: 914389-32-5
• Molecular Formula: C₂₁H₂₂N₂O₄
• Molecular Weight: 366.41
• Mol File: 914389-32-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 614.3°C at 760 mmHg
• Flash Point: 325.3°C
• Density: 1.31g/cm³
• Vapor Pressure: 5.03E-15mmHg at 25°C
• Refractive Index: 1.641
• CAS DataBase Reference: benzyl 2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate(914389-32-5)
• EPA Substance Registry System: benzyl 2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate(914389-32-5)

Safety Data

• Hazardous Substances Data: 914389-32-5(Hazardous Substances Data)

Upstream product

• 61350-60-5 (S)-benzyloxycarbonyl-proline acid chloride 
• 32752-37-7 1,3,5-tris(4-methoxyphenyl)-1,3,5-triazinane 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 914389-55-2 (R)-2-({[(R)-1-Benzyloxycarbonyl-2-({[(R)-1-benzyloxycarbonyl-2-(tert-butoxycarbonylamino-methyl)-pyrrolidine-2-carbonyl]-amino}-methyl)-pyrrolidine-2-carbonyl]-amino}-methyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 914389-54-1 (R)-2-({[(R)-1-Benzyloxycarbonyl-2-(tert-butoxycarbonylamino-methyl)-pyrrolidine-2-carbonyl]-amino}-methyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 914389-48-3 (4R)-2-[3-aza-4-(benzyloxycarbonyl)-2-oxobutyl]-5-[(2S)-1-tert-butoxycarbonylpyrrolidin-2-ylcarbonyl]-2,5-diazaspiro[3,4]octan-1-one 
• 914389-46-1 (4R)-2-[(benzyloxycarbonyl)methyl]-5-[(2S)-1-tert-butoxycarbonylpyrrolidin-2-ylcarbonyl]-2,5-diazaspiro[3,4]octan-1-one 
• 914389-44-9 (4R)-5-[(2S)-1-tert-butoxycarbonylpyrrolidin-2-ylcarbonyl]-2-(4-methoxyphenyl)-2,5-diazaspiro[3,4]octan-1-one 
• 914389-47-2 (S)-2-((R)-2-Carboxymethyl-1-oxo-2,5-diaza-spiro[3.4]octane-5-carbonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 914389-53-0 2-(tert-butoxycarbonylamino-methyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 
• 914389-52-9 2-(tert-butoxycarbonylamino-methyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 914389-50-7 (4R)-5-benzyloxycarbonyl-2-(4-methoxyphenyl)-2,5-diazaspiro[3,4]octan-1-one 
• 914389-51-8 (4R)-5-benzyloxycarbonyl-2-(tert-butoxycarbonyl)-2,5-diazaspiro[3,4]octan-1-one 
• 914389-38-1 (4S)-2-(4-methoxyphenyl)-2,5-diazaspiro[3,4]octan-1-one 
• 914389-40-5 (4R)-2-(4-methoxyphenyl)-2,5-diazaspiro[3,4]octan-1-one 
• 914389-34-7 benzyl 2-(4-methoxybenzyl)-1-oxo-2,5-diazaspiro[3.4]-octane-5-carboxylate 
• 914389-37-0 (+/-)-2-(4-methoxyphenyl)-2,5-diazaspiro[3,4]octan-1-one 

Relevant articles and documents

SECONDARY STRUCTURE STABILIZED NMDA RECEPTOR MODULATORS AND USES THEREOF

Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of diseases and disorders such as learning, cognitive activities, and analgesia, particularly in alleviat

Synthesis of enantiopure pyrrolidine-derived peptidomimetics and oligo-β-peptides via nucleophilic ring-opening of β-lactams

(Chemical Equation Presented) The synthesis of the two enantiomers of pyrrolidine-derived spiro β-lactams by resolution with D- and L-Boc phenylalanine is described. The potential of these optically active spiro β-lactams on the synthesis of peptidomimetics as analogues of melanostatin is evaluated. Theoretical studies of several models, at the Becke3LYP/6-31+G* level of theory, together with previous experimental evidences from our group, gathered by NMR, allow us to design structures that can efficiently mimic some biologically active peptide-type molecules. On the other hand, the spiro β-lactams have shown their utility in the preparation of β-peptides. As an example, a homo-tetra-β-peptide was synthesized. This research will continue in the future in order to obtain higher peptides with potential biological activity.