4-Methoxy-1,4'-bipiperidine

Base Information

• Chemical Name: 4-Methoxy-1,4'-bipiperidine
• CAS No.: 930603-98-8
• Molecular Formula: C11H22N2O
• Molecular Weight: 198.308
• DSSTox Substance ID: DTXSID00655938
• Wikidata: Q82570329
• Mol file: 930603-98-8.mol

Synonyms:4-methoxy-1,4'-bipiperidine;930603-98-8;4-methoxy-[1,4']bipiperidinyl;4-methoxy-1-piperidin-4-ylpiperidine;4-Methoxy-[1,4`]bipiperidinyl;MFCD09998983;SCHEMBL233141;DTXSID00655938;QYTOCUJJGMOUDF-UHFFFAOYSA-N;AMY34978;AKOS009464987;SB13151;4-methoxy-1-(piperidin-4-yl)piperidine;AS-53114;CS-0050825;EN300-242579;P16094;1-(4-PIPERIDINYL)-4-METHOXY-PIPERIDINE

Chemical Property of 4-Methoxy-1,4'-bipiperidine

Chemical Property:

• Vapor Pressure: 0.005mmHg at 25°C
• Boiling Point: 277.498°C at 760 mmHg
• Flash Point: 121.627°C
• Density: 1.018g/cm³
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 198.173213330
• Heavy Atom Count: 14
• Complexity: 161

Purity/Quality:

99%, ^*data from raw suppliers

4-Methoxy-1,4''-bipiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1CCN(CC1)C2CCNCC2

Technology Process of 4-Methoxy-1,4'-bipiperidine

There total 6 articles about 4-Methoxy-1,4'-bipiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1'-benzyl-4-methoxy-[1,4']bipiperidinyl bis-hydrochloride → 4-methoxy-1, 4′-bipiperidine (930603-98-8)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; water; at 20 ℃; for 8h; under 2250.23 Torr;

Reference yield:

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) + 4-methoxypiperidine hydrochloride (4045-25-4) → 4-methoxy-1, 4′-bipiperidine (930603-98-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / tetrahydrofuran; methanol / 0.5 h / 20 - 45 °C

1.2: 6.5 h

1.3: pH 9

2.1: hydrogen

With hydrogen; acetic acid; In tetrahydrofuran; methanol;

Reference yield:

benzyl 4-methoxy-[1,4′-bipiperidine]-1′-carboxylate (1192122-31-8) → 4-methoxy-1, 4′-bipiperidine (930603-98-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;

upstream raw materials:

benzyl 4-methoxy-[1,4′-bipiperidine]-1′-carboxylate

4-methoxypiperidine

benzyl 4-oxo-1-piperidinecarboxylate

4-methoxypiperidine hydrochloride

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