7-Chloro-4-Methoxy-1(2H)-...

Base Information

• Chemical Name: 7-Chloro-4-Methoxy-1(2H)-...
• CAS No.: 630423-35-7
• Molecular Formula: C₁₀H₈ClNO₂
• Molecular Weight: 209.632
• Hs Code.: 2933990090
• Mol file: 630423-35-7.mol

Synonyms:7-Chloro-4-Methoxy-1(2H)-...;7-Chloro-4-Methoxy-1(2H)-isoquinolinone;7-chloro-4-methoxy-1,2-dihydroisoquinolin-1-one;7-Chloro-4-methoxyisoquinolin-1(2H)-one;7-chloro-4-methoxy-2H-isoquinolin-1-one

Chemical Property of 7-Chloro-4-Methoxy-1(2H)-...

Chemical Property:

• Boiling Point: 460.8±45.0 °C(Predicted)
• PKA: 10.90±0.40(Predicted)
• PSA: 42.35000
• Density: 1.37±0.1 g/cm3(Predicted)
• LogP: 2.60240

Purity/Quality:

99.9% ^*data from raw suppliers

7-Chloro-4-methoxy-1(2H)-isoquinolinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Chloro-4-Methoxy-1(2H)-...

There total 3 articles about 7-Chloro-4-Methoxy-1(2H)-... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.95%

methanol (67-56-1) + C9H6ClNO2 (1210474-91-1) → 7-chloro-4-methoxy-2H-isoquinolin-1-one (630423-35-7)

Guidance literature:

With methanesulfonic acid; at 3 - 60 ℃;

Reference yield: 85.0%

methanol (67-56-1) + 7-chloroisoquinoline-1(2Η)-one (24188-74-7) → 7-chloro-4-methoxy-2H-isoquinolin-1-one (630423-35-7)

Guidance literature:

With methanesulfonic acid; [bis(acetoxy)iodo]benzene; Inert atmosphere; Cooling with ice; Reflux;

Reference yield: 3.0%

→ 7-chloro-4-methoxy-2H-isoquinolin-1-one (630423-35-7)

Guidance literature:

upstream raw materials:

methanol

7-chloroisoquinoline-1(2Η)-one

C₉H₆ClNO₂

Downstream raw materials:

1,7-dichloro-4-methoxyisoquinoline