Montelukast Sulfone

Base Information

Chemical Name:Montelukast Sulfone
CAS No.:1266620-74-9
Molecular Formula:C₃₅H₃₆ClNO₅S
Molecular Weight:618.194
Hs Code.:
Mol file:1266620-74-9.mol

Synonyms:Montelukast Sulfone ;1-[[[1-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-Methylethyl)phenyl]propyl]sulfonyl]Methyl]cyclopropaneacetic Acid

Suppliers and Price of Montelukast Sulfone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
MontelukastSulfone
10mg
$ 290.00

Total 12 raw suppliers

Chemical Property of Montelukast Sulfone

Chemical Property:

Boiling Point:828.0±65.0 °C(Predicted)
PKA:4.76±0.10(Predicted)
PSA：112.94000
Density:1.321±0.06 g/cm3(Predicted)
LogP:8.71040
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

MontelukastSulfone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Montelukast Sulfone

There total 10 articles about Montelukast Sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1197374-09-6
(S)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propyl acetate

: 1266620-74-9
[R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2-(hydroxy-1-methylethyl)phenyl]propyl]-sulfonyl]methyl]-cyclopropane acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: water; sodium hydroxide / tetrahydrofuran; methanol / 25 - 30 °C

2.1: hydrogenchloride / water; ethyl acetate / 25 - 30 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 25 - 30 °C

3.2: 1 h / 0 - 5 °C

4.1: sodium methylate / methanol; N,N-dimethyl-formamide / 0 - 5 °C

5.1: ethyl acetate / 25 - 30 °C

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 25 - 30 °C

7.1: sulfuric acid; water / 5 - 10 °C

With hydrogenchloride; sulfuric acid; water; sodium methylate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1197374-12-1
[1-[(R)-1-(3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]-phenyl)-3-(2-isopropenylphenyl)propylsulfanylmethyl]cyclopropyl]acetic acid dicyclohexylamine salt

: 1266620-74-9
[R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2-(hydroxy-1-methylethyl)phenyl]propyl]-sulfonyl]methyl]-cyclopropane acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 25 - 30 °C

2: sulfuric acid; water / 5 - 10 °C

With sulfuric acid; water; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

Reference yield:

: 1197374-10-9
(S)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propan-1-ol hydrochloride

: 1266620-74-9
[R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2-(hydroxy-1-methylethyl)phenyl]propyl]-sulfonyl]methyl]-cyclopropane acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 25 - 30 °C

1.2: 1 h / 0 - 5 °C

2.1: sodium methylate / methanol; N,N-dimethyl-formamide / 0 - 5 °C

3.1: ethyl acetate / 25 - 30 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 25 - 30 °C

5.1: sulfuric acid; water / 5 - 10 °C

With sulfuric acid; water; sodium methylate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;