Montelukast Sulfone

Base Information

• Chemical Name: Montelukast Sulfone
• CAS No.: 1266620-74-9
• Molecular Formula: C₃₅H₃₆ClNO₅S
• Molecular Weight: 618.194
• Mol file: 1266620-74-9.mol

Synonyms:Montelukast Sulfone ;1-[[[1-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-Methylethyl)phenyl]propyl]sulfonyl]Methyl]cyclopropaneacetic Acid

Chemical Property of Montelukast Sulfone

Chemical Property:

• Boiling Point: 828.0±65.0 °C(Predicted)
• PKA: 4.76±0.10(Predicted)
• PSA: 112.94000
• Density: 1.321±0.06 g/cm3(Predicted)
• LogP: 8.71040
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

> 95% ^*data from raw suppliers

MontelukastSulfone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Montelukast Sulfone

There total 10 articles about Montelukast Sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propyl acetate (1197374-09-6) → [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2-(hydroxy-1-methylethyl)phenyl]propyl]-sulfonyl]methyl]-cyclopropane acetic acid (1266620-74-9)

Guidance literature:

Multi-step reaction with 7 steps

1.1: water; sodium hydroxide / tetrahydrofuran; methanol / 25 - 30 °C

2.1: hydrogenchloride / water; ethyl acetate / 25 - 30 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 25 - 30 °C

3.2: 1 h / 0 - 5 °C

4.1: sodium methylate / methanol; N,N-dimethyl-formamide / 0 - 5 °C

5.1: ethyl acetate / 25 - 30 °C

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 25 - 30 °C

7.1: sulfuric acid; water / 5 - 10 °C

With hydrogenchloride; sulfuric acid; water; sodium methylate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

[1-[(R)-1-(3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]-phenyl)-3-(2-isopropenylphenyl)propylsulfanylmethyl]cyclopropyl]acetic acid dicyclohexylamine salt (1197374-12-1) → [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2-(hydroxy-1-methylethyl)phenyl]propyl]-sulfonyl]methyl]-cyclopropane acetic acid (1266620-74-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 25 - 30 °C

2: sulfuric acid; water / 5 - 10 °C

With sulfuric acid; water; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

Reference yield:

(S)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propan-1-ol hydrochloride (1197374-10-9) → [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2-(hydroxy-1-methylethyl)phenyl]propyl]-sulfonyl]methyl]-cyclopropane acetic acid (1266620-74-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 25 - 30 °C

1.2: 1 h / 0 - 5 °C

2.1: sodium methylate / methanol; N,N-dimethyl-formamide / 0 - 5 °C

3.1: ethyl acetate / 25 - 30 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 25 - 30 °C

5.1: sulfuric acid; water / 5 - 10 °C

With sulfuric acid; water; sodium methylate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

[R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-[1-(1-methyl)ethenyl]phenyl]propyl]thio]methyl]cyclopropaneacetic acid

(S)-1-(3-((E)-2-(7-chloroquinolin?2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propyl methanesulphonate

(S)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propyl acetate

[1-[(R)-1-(3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]-phenyl)-3-(2-isopropenylphenyl)propylsulfanylmethyl]cyclopropyl]acetic acid dicyclohexylamine salt