Montelukast Styrene

Base Information

Chemical Name:Montelukast Styrene
CAS No.:918972-54-0
Molecular Formula:C35H34ClNO2S
Molecular Weight:568.179
Hs Code.:29339900
Mol file:918972-54-0.mol

Synonyms:CYC128;UNII-H5EKP57W1I;Montelukast Styrene;Montelukast methylstyrene;Montelukast Impurity;

Suppliers and Price of Montelukast Styrene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Montelukast Styrene
1mg
$ 602.00

TRC
MontelukastStyrene
5mg
$ 675.00

AvaChem
Montelukast Methylstyrene
25mg
$ 425.00

AvaChem
Montelukast Methylstyrene
10mg
$ 225.00

AvaChem
Montelukast Methylstyrene
5mg
$ 125.00

American Custom Chemicals Corporation
MONTELUKAST METHYLSTYRENE IMPURITY 95.00%
5MG
$ 503.24

American Custom Chemicals Corporation
MONTELUKAST STYRENE 95.00%
5MG
$ 495.26

Total 21 raw suppliers

Chemical Property of Montelukast Styrene

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:154-156°C
Boiling Point:729.2±60.0 °C(Predicted)
PKA:4.76±0.10(Predicted)
PSA：75.49000
Density:1.238±0.06 g/cm3(Predicted)
LogP:9.75370
Storage Temp.:-20°C Freezer, Under Inert Atmosphere
Solubility.:Chloroform (Slightly), DMSO (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

Montelukast Styrene ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Montelukast Styrene (Montelukast EP Impurity B; Montelukast USP Related Compound F; Montelukast Methylstyrene; Styrene Montelukast) is a Montelukast impurity.

Technology Process of Montelukast Styrene

There total 8 articles about Montelukast Styrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 158966-92-8
montelukast

: 918972-54-0
[R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-[1-(1-methyl)ethenyl]phenyl]propyl]thio]methyl]cyclopropaneacetic acid

Guidance literature:: With maleic acid; In toluene; at 5 - 25 ℃; for 6h; Heating / reflux;

Reference yield:

: 1197374-09-6
(S)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propyl acetate

: 918972-54-0
[R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-[1-(1-methyl)ethenyl]phenyl]propyl]thio]methyl]cyclopropaneacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; sodium hydroxide / tetrahydrofuran; methanol / 25 - 30 °C

2.1: hydrogenchloride / water; ethyl acetate / 25 - 30 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 25 - 30 °C

3.2: 1 h / 0 - 5 °C

4.1: sodium methylate / methanol; N,N-dimethyl-formamide / 0 - 5 °C

With hydrogenchloride; water; sodium methylate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1197374-10-9
(S)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propan-1-ol hydrochloride

: 918972-54-0
[R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-[1-(1-methyl)ethenyl]phenyl]propyl]thio]methyl]cyclopropaneacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 25 - 30 °C

1.2: 1 h / 0 - 5 °C

2.1: sodium methylate / methanol; N,N-dimethyl-formamide / 0 - 5 °C

With sodium methylate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;