(S)-1-(3-((E)-2-(7-chloroquinolin?2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propyl methanesulphonate

Base Information

Chemical Name:(S)-1-(3-((E)-2-(7-chloroquinolin?2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propyl methanesulphonate
CAS No.:1197374-11-0
Molecular Formula:C₃₀H₂₈ClNO₃S
Molecular Weight:518.076
Hs Code.:

Synonyms:(S)-1-(3-((E)-2-(7-chloroquinolin?2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propyl methanesulphonate

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Chemical Property of (S)-1-(3-((E)-2-(7-chloroquinolin?2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propyl methanesulphonate

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Technology Process of (S)-1-(3-((E)-2-(7-chloroquinolin?2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propyl methanesulphonate

There total 7 articles about (S)-1-(3-((E)-2-(7-chloroquinolin?2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propyl methanesulphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1197374-10-9
(S)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propan-1-ol hydrochloride

: 124-63-0
methanesulfonyl chloride

: 1197374-11-0
(S)-1-(3-((E)-2-(7-chloroquinolin?2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propyl methanesulphonate

Guidance literature:: (S)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propan-1-ol hydrochloride; With ammonia; In dichloromethane; water; at 25 - 30 ℃; for 0.666667h; pH=7.5 - 8.0;

methanesulfonyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -30 - -25 ℃; for 3h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 1197374-09-6
(S)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propyl acetate

: 1197374-11-0
(S)-1-(3-((E)-2-(7-chloroquinolin?2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propyl methanesulphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; sodium hydroxide / tetrahydrofuran; methanol / 25 - 30 °C

2.1: hydrogenchloride / water; ethyl acetate / 25 - 30 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 25 - 30 °C

3.2: 1 h / 0 - 5 °C

With hydrogenchloride; water; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 869066-93-3
(S)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl acetate

: 1197374-11-0
(S)-1-(3-((E)-2-(7-chloroquinolin?2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propyl methanesulphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 25 - 30 °C

2.1: water; sodium hydroxide / tetrahydrofuran; methanol / 25 - 30 °C

3.1: hydrogenchloride / water; ethyl acetate / 25 - 30 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 25 - 30 °C

4.2: 1 h / 0 - 5 °C

With hydrogenchloride; water; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;