2-Acetyl-5-broMopyrrole

Base Information

• Chemical Name: 2-Acetyl-5-broMopyrrole
• CAS No.: 51333-64-3
• Molecular Formula: C6H6BrNO
• Molecular Weight: 188.02194
• Mol file: 51333-64-3.mol

Synonyms:2-Acetyl-5-broMopyrrole;1-(4-bromo-1H-pyrrol-2-yl)ethanone

Chemical Property of 2-Acetyl-5-broMopyrrole

Chemical Property:

• PSA: 32.86000
• LogP: 1.97980

Purity/Quality:

99% ^*data from raw suppliers

1-(4-bromo-1H-pyrrol-2-yl)ethanone 95%-98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Acetyl-5-broMopyrrole

There total 3 articles about 2-Acetyl-5-broMopyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-Acetylpyrrole (1072-83-9) → 1-(4-bromo-1H-pyrrol-2-yl)ethan-1-one (51333-64-3)

Guidance literature:

With oxone; sodium bromide; In methanol; water; regioselective reaction;

DOI:10.1002/ejoc.201100324

Reference yield:

1,4-dioxane (123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6) + 2-Acetylpyrrole (1072-83-9) + bromine (7726-95-6) → 1-(4-bromo-1H-pyrrol-2-yl)ethan-1-one (51333-64-3)

Guidance literature:

DOI:10.1021/ja01492a021

Reference yield:

2-Acetylpyrrole (1072-83-9) → 1-(4-bromo-1H-pyrrol-2-yl)ethan-1-one (51333-64-3) + 2-acetyl-3,4,5-tribromopyrrole (393819-18-6) + 2,2-dibromo-1-(3,4,5-tribromo-pyrrol-2-yl)-ethanone

Guidance literature:

Bromierung;

upstream raw materials:

2-Acetylpyrrole

1,4-dioxane

bromine

Refernces

• 1、 Bao, Xiaoguang,Fu, Rui,Gao, Ke,Jin, Feng,Pan, Lei,Zhou, Shaofang. "Oxidative Ring-Opening of 1H-Pyrazol-5-amines and Its Application in Constructing Pyrazolo–Pyrrolo–Pyrazine Scaffolds by Domino Cyclization". supporting information. p. 2956 - 2961. Retrieved 2020/05/16.
• 2、 -. "INHIBITORS OF ACTIVIN RECEPTOR-LIKE KINASE". Page/Page column 228. . Retrieved 2017/11/10.