tert-butyl 4-(3-(methoxycarbonyl)phenyl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(3-(methoxycarbonyl)phenyl)piperidine-1-carboxylate
• CAS No.: 1016980-41-8
• Molecular Formula: C18H25NO4
• Molecular Weight: 319.401
• Mol file: 1016980-41-8.mol

Synonyms:tert-butyl 4-(3-(methoxycarbonyl)phenyl)piperidine-1-carboxylate;1-Boc-4-[3-(methoxycarbonyl)phenyl]piperidine

Chemical Property of tert-butyl 4-(3-(methoxycarbonyl)phenyl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

NLT 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-(3-(methoxycarbonyl)phenyl)piperidine-1-carboxylate

There total 4 articles about tert-butyl 4-(3-(methoxycarbonyl)phenyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

methyl 3-(piperidin-4-yl)benzoate (744197-23-7) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 4-(3-(methoxycarbonyl)phenyl)piperidine-1-carboxylate (1016980-41-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield: 79.0%

methyl 3-bromobenzoate (618-89-3) + 1-(1-(tert-butoxycarbonyl)piperidin-4-yl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate → tert-butyl 4-(3-(methoxycarbonyl)phenyl)piperidine-1-carboxylate (1016980-41-8)

Guidance literature:

With nickel(II) bromide diethylene glycol dimethyl ether; 4,4'-Dimethoxy-2,2'-bipyridin; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; In N,N-dimethyl acetamide; at 20 ℃; for 16h; Irradiation;

DOI:10.1021/acscatal.1c01416

Reference yield: 71.0%

methyl 3-chlorobenzoate (2905-65-9) + tert-butyl 4-bromo-1-piperidinecarboxylate (180695-79-8) → tert-butyl 4-(3-(methoxycarbonyl)phenyl)piperidine-1-carboxylate (1016980-41-8)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; methyl octanate; C₄₇H₆₄NO₄PPdS; sodium caprylate; sodium chloride; zinc; In water; at 45 ℃; for 36h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201509341

upstream raw materials:

methyl 3-chlorobenzoate

tert-butyl 4-bromo-1-piperidinecarboxylate

methyl 3-(piperidin-4-yl)benzoate

di-tert-butyl dicarbonate

Refernces

• 1、 -. "TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE". Page/Page column 87. . Retrieved 2017/10/18.
• 2、 -. "TRIAZOLOPYRIDINE AND TRIAZOLOPYRIMIDINE INHIBITORS OF MYELOPEROXIDASE". Paragraph 00321. . Retrieved 2016/06/01.