4-methyl-6-quinolinecarboxaldehyde

Base Information

• Chemical Name: 4-methyl-6-quinolinecarboxaldehyde
• CAS No.: 916812-60-7
• Molecular Formula: C₁₁H₉NO
• Molecular Weight: 171.199
• Mol file: 916812-60-7.mol

Synonyms:4-methyl-6-quinolinecarboxaldehyde;4-methylquinoline-6-carbaldehyde

Chemical Property of 4-methyl-6-quinolinecarboxaldehyde

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

4-methyl-6-Quinolinecarboxaldehyde 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-6-quinolinecarboxaldehyde

There total 3 articles about 4-methyl-6-quinolinecarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

→ 6-formyl-4-methylquinoline (916812-60-7)

Guidance literature:

Reference yield: 38.0%

formic acid (64-18-6) + 6-iodo-4-methylquinoline (57830-59-8) → 6-formyl-4-methylquinoline (916812-60-7)

Guidance literature:

With iodine; palladium diacetate; triethylamine; triphenylphosphine; In toluene; at 80 ℃; for 6h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1002/asia.202100704

Reference yield:

6-bromo-4-methylquinoline (41037-28-9) → 6-formyl-4-methylquinoline (916812-60-7)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; N,N`-dimethylethylenediamine; sodium iodide / 1,4-dioxane / 16 h / 110 °C / Inert atmosphere; Sealed tube

2: triethylamine; palladium diacetate; triphenylphosphine; iodine / toluene / 6 h / 80 °C / Schlenk technique; Inert atmosphere; Sealed tube

With copper(l) iodide; iodine; palladium diacetate; triethylamine; triphenylphosphine; sodium iodide; N,N`-dimethylethylenediamine; In 1,4-dioxane; toluene;

DOI:10.1002/asia.202100704

upstream raw materials:

formic acid

6-iodo-4-methylquinoline

6-bromo-4-methylquinoline

Downstream raw materials:

4-methyl-6-quinolinecrboxylic acid

Refernces

• 1、 -. "NOVEL CHEMICAL COMPOUNDS". Page/Page column 55. . Retrieved 2010/11/25.