5-[4-(TRIFLUOROMETHYL)PHENYL]-2-PYRIDINAMINE

Base Information

• Chemical Name: 5-[4-(TRIFLUOROMETHYL)PHENYL]-2-PYRIDINAMINE
• CAS No.: 893738-30-2
• Molecular Formula: C12H9F3N2
• Molecular Weight: 238.21
• Hs Code.: 2933399090
• Mol file: 893738-30-2.mol

Synonyms:AKOS BAR-0882;5-[4-(TRIFLUOROMETHYL)PHENYL]-2-PYRIDINAMINE

Chemical Property of 5-[4-(TRIFLUOROMETHYL)PHENYL]-2-PYRIDINAMINE

Chemical Property:

• PSA: 39.64000
• LogP: 3.27970

Purity/Quality:

95+% ^*data from raw suppliers

5-(4-Trifluoromethylphenyl)-pyridin-2-ylamine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-[4-(TRIFLUOROMETHYL)PHENYL]-2-PYRIDINAMINE

There total 2 articles about 5-[4-(TRIFLUOROMETHYL)PHENYL]-2-PYRIDINAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

→ 5-(4-trifluoromethyl-phenyl)pyridin-2-ylamine (893738-30-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; water; at 80 ℃; Inert atmosphere;

Reference yield: 45.0%

5-bromo-2-pyridylamine (1072-97-5) + 4-trifluoromethylphenylboronic acid (128796-39-4) → 5-(4-trifluoromethyl-phenyl)pyridin-2-ylamine (893738-30-2)

Guidance literature:

With palladium diacetate; sodium carbonate; In water; N,N-dimethyl-formamide; at 110 ℃; for 3h;

DOI:10.1021/jm8004509

Reference yield: 52.0%

5-(4-trifluoromethyl-phenyl)pyridin-2-ylamine (893738-30-2) + benzoyl chloride (98-88-4) → N-{5-[4-(trifluoromethyl)phenyl]pyridin-2-yl}benzamide (1044239-35-1)

Guidance literature:

With pyridine; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm8004509

upstream raw materials:

5-bromo-2-pyridylamine

4-trifluoromethylphenylboronic acid

Downstream raw materials:

N-{5-[4-(trifluoromethyl)phenyl]pyridin-2-yl}benzamide

Refernces

• 1、 Heitman, Laura H.,Van Veldhoven, Jacobus P. D.,Zweemer, Annelien M.,Ye, Kai,Brussee, Johannes,Ijzerrnan, Adriaan P.. "False positives in a reporter gene assay: Identification and synthesis of substituted N-pyridin-2-ylbenzamides as competitive inhibitors of firefly luciferase". supporting information; experimental part. p. 4724 - 4729. Retrieved 2009/06/18.