1-(2-Methoxyphenyl)cyclopropane-1-carboxylic acid

Base Information

• Chemical Name: 1-(2-Methoxyphenyl)cyclopropane-1-carboxylic acid
• CAS No.: 74205-24-6
• Molecular Formula: C11H12O3
• Molecular Weight: 192.214
• Hs Code.: 2918990090
• European Community (EC) Number: 833-661-6
• DSSTox Substance ID: DTXSID20593388
• Wikidata: Q82487872
• Mol file: 74205-24-6.mol

Synonyms:74205-24-6;1-(2-methoxyphenyl)cyclopropane-1-carboxylic acid;1-(2-Methoxyphenyl)cyclopropanecarboxylic acid;MFCD00297169;SCHEMBL1465128;DTXSID20593388;CZPYUTXQDVNAFL-UHFFFAOYSA-N;AKOS009264984;AB05941;AS-46664;SY101815;DB-290607;1-(2-Methoxyphenyl)cyclopropanecarboxylicacid;EN300-61674;1-(2-methoxyphenyl)cyclopropane carboxylic acid;E10036;A915742;1-(2-Methoxyphenyl)cyclo-propane-1-carboxylic acid;F2189-0462;Z361883644;1-(2-methoxyphenyl)cyclopropanecarboxylic acid, AldrichCPR;1-(2-Methoxyphenyl)cyclopropane-1-carboxylic acid - NEW PRODUCT

Chemical Property of 1-(2-Methoxyphenyl)cyclopropane-1-carboxylic acid

Chemical Property:

• PSA: 46.53000
• LogP: 1.81140
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 192.078644241
• Heavy Atom Count: 14
• Complexity: 233

Purity/Quality:

98%min ^*data from raw suppliers

1-(2-Methoxyphenyl)cyclopropane-1-carboxylicacid 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1C2(CC2)C(=O)O
• Uses: 1-(2-Methoxyphenyl)cyclopropane-1-carboxylic acid is used as a reactant in the preparation of N-pyridinyl carboxamide derivatives as modulators of atp-binding cassette transporters.

Technology Process of 1-(2-Methoxyphenyl)cyclopropane-1-carboxylic acid

There total 3 articles about 1-(2-Methoxyphenyl)cyclopropane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

aqueous potassium hydroxide + 1-(2-Methoxy-phenyl)-cyclopropanecarbonitrile (74204-96-9) → 1-(2-methoxyphenyl)cyclopropane-1-carboxylic acid (74205-24-6)

Guidance literature:

Reference yield:

2-methoxy-benzeneacetonitrile (7035-03-2) → 1-(2-methoxyphenyl)cyclopropane-1-carboxylic acid (74205-24-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) sodium amide / 1.) toluene, heating, 1 h, 2.) overnight; heating, 6 h

2: 72.7 percent / KOH / bis-(2-hydroxy-ethyl) ether / 8 h / Heating

With potassium hydroxide; sodium amide; In diethylene glycol;

DOI:10.1007/BF00765910

Reference yield:

→ 1-(2-methoxyphenyl)cyclopropane-1-carboxylic acid (74205-24-6)

Guidance literature:

upstream raw materials:

2-methoxy-benzeneacetonitrile

1-(2-Methoxy-phenyl)-cyclopropanecarbonitrile

Downstream raw materials:

C₃₁H₃₂N₂O₅S₂

C₃₂H₃₄N₂O₃S

methyl 1-(2-methoxyphenyl)cyclopropane-1-carboxylate

(2S,5R,6R)-6-{[1-(2-Methoxy-phenyl)-cyclopropanecarbonyl]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

Refernces

• 1、 -. "Tetraisoquinoline compounds which have useful pharmaceutical utility". . . Retrieved 2008/06/13.