74204-96-9

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(2-METHOXY-PHENYL)-CYCLOPROPANECARBONITRILE is used as a building block for the synthesis of pharmaceuticals due to its ability to form heterocyclic structures, which are common in many drug molecules.
Used in Organic Synthesis:
In the field of organic synthesis, 1-(2-METHOXY-PHENYL)-CYCLOPROPANECARBONITRILE is used as a versatile intermediate for the creation of a variety of organic compounds, leveraging its cyclopropane ring and cyano group for structural diversity.
Used in Transition Metal-Catalyzed Reactions:
1-(2-METHOXY-PHENYL)-CYCLOPROPANECARBONITRILE is utilized as a ligand in transition metal-catalyzed reactions, taking advantage of its structural features to facilitate specific types of chemical transformations.
Used in Derivatization for Further Synthesis:
The methoxy group on the phenyl ring of 1-(2-METHOXY-PHENYL)-CYCLOPROPANECARBONITRILE is used as a handle for further derivatization, allowing for the attachment of various functional groups to create new compounds with tailored properties for specific applications.

InChI:InChI=1/C11H11NO/c1-13-10-5-3-2-4-9(10)11(8-12)6-7-11/h2-5H,6-7H2,1H3

Upstream product

• 7035-03-2 2-methoxy-benzeneacetonitrile 
• 106-93-4 ethylene dibromide 
• 321-28-8 1-fluoro-2-methoxybenzene 
• 5500-21-0 cyclopropropanecarbonitrile 
• 107-06-2 1,2-dichloro-ethane 

Downstream Products

• 74205-24-6 1-(2-methoxyphenyl)cyclopropane-1-carboxylic acid 
• 502159-61-7 1-(2-methoxy-phenyl)-cyclopropanecarboxamidine 
• 502159-62-8 4-(2,4-dichloro-phenyl)-2-[1-(2-methoxy-phenyl)-cyclopropyl]-5-methyl-pyrimidine 
• 61492-17-9 (2S,5R,6R)-6-{[1-(2-Methoxy-phenyl)-cyclopropanecarbonyl]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 

Relevant academic research and scientific papers

Efficient cyclopropanation of aryl/heteroaryl acetates and acetonitriles with vinyl diphenyl sulfonium triflate

A convenient method was developed for the cyclopropanation of aryl acetates and aryl acetonitrile using vinyl diphenyl sulfonium triflate salt. The newly developed conditions are simple, mild, and compatible with a wide range of functional groups, without the need to apply an inert atmosphere, or alkali bases.

Heteroaromatic substituted cyclopropane as corticotropin releasing hormone ligands

Provided herein are novel heteroaromatic substituted cyclopropanes of the Formula (I): as well as compositions, including pharmaceutical compositions, containing the same, and the use thereof in the treatment of various neurological and psychological diso

Nonsteroidal gestagens

This invention describes the new, nonsteroidal gestagens of general formula I in which A, B, Ar, R1, R2and R3have the meanings that are indicated in more detail in the description. The new compounds show a very great affin

Process for preparing benzylnitriles

A process is described for preparing an aromatic compound substituted by a tertiary nitrile of Formula (1.0.0): comprising treating a substituted aromatic compound of Formula (2.0.0): with a secondary nitrile of Formula (3.0.0): in the presence of a base having a pKanumerical value in the range of from about 17 to about 30, provided that the difference in pKanumerical values between said base and the corresponding tertiary nitrile of Formula (3.0.0) is no more than about 6; in an aprotic solvent having a dielectric constant (∈) of less than about 20; and at a reaction temperature in the range of from about 0° C. to about 120° C.; whereby there is formed said tertiary-nitrile-substituted aromatic compound final product of Formula (1.0.0); wherein the constituent parts W1, W2, W3, W4, and W5; and the substituent moieties R1, R2, R3, R4, R5, R6, and R7in the compounds of Formulas (1.0.0), (2.0.0) and (3.0.0) are selected from known organic groups and radicals as further detailed in the instant specification.

Tetraisoquinoline compounds which have useful pharmaceutical utility

Tetrahydroisoquinoline compounds of formula I STR1 and pharmaceutically acceptable salts and lipophilic ester thereof have utility as analgesics and in the treatment of psychoses, Parinson''s disease, Lesch-Nyan syndrome, attention deficit disorder or cognitive impairment or in the relief of drug dependence or tardive dyskinesia.