[(R)-2-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-2-oxo-1-[(benzylthio)methyl]ethyl]carbamic acid benzyl ester

Base Information

• Chemical Name: [(R)-2-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-2-oxo-1-[(benzylthio)methyl]ethyl]carbamic acid benzyl ester
• CAS No.: 3401-57-8
• Molecular Formula: C22H22N2O6S
• Molecular Weight: 442.48
• Mol file: 3401-57-8.mol

Synonyms:[(R)-2-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-2-oxo-1-[(benzylthio)methyl]ethyl]carbamic acid benzyl ester;CarbaMic acid, [2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxo-1-[[(phenylMethyl)thio]Methyl]ethyl]-, phenylMethyl ester, (R)-

Chemical Property of [(R)-2-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-2-oxo-1-[(benzylthio)methyl]ethyl]carbamic acid benzyl ester

Chemical Property:

• PSA: 127.31000
• LogP: 3.15080

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [(R)-2-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-2-oxo-1-[(benzylthio)methyl]ethyl]carbamic acid benzyl ester

There total 3 articles about [(R)-2-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-2-oxo-1-[(benzylthio)methyl]ethyl]carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

benzyloxycarbonyl-S-benzylcysteine (3257-18-9) + 1,2,2,2-tetrachloroethyl-(N-succinimidyl)carbonate (107960-02-1) → N-benzyloxycarbonyl-S-benzyl-L-cysteine succinimido-ester (3401-57-8)

Guidance literature:

With 4-methyl-morpholine; In tetrahydrofuran; acetonitrile; Ambient temperature;

DOI:10.1021/jo00388a005

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + benzyloxycarbonyl-S-benzylcysteine (3257-18-9) → N-benzyloxycarbonyl-S-benzyl-L-cysteine succinimido-ester (3401-57-8)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃; for 3.5h;

DOI:10.1021/jm00044a003

Reference yield:

→ N-benzyloxycarbonyl-S-benzyl-L-cysteine succinimido-ester (3401-57-8)

Guidance literature:

entspr.Cystein, N-Hydroxysuccinimid;

DOI:10.1021/jo00827a053

upstream raw materials:

benzyloxycarbonyl-S-benzylcysteine

1,2,2,2-tetrachloroethyl-(N-succinimidyl)carbonate

1-hydroxy-pyrrolidine-2,5-dione

Downstream raw materials:

N-benzyloxycarbonyl-S-benzyl-L-cysteinyldiglycyl-S-benzyl-L-cysteinyldiglycyl-S-benzyl-L-cysteinyldiglycyl-S-benzyl-L-cysteinylglycylglycinamide

N-acetyldiglycyl-S-benzyl-L-cysteinyldiglycyl-S-benzyl-L-cysteinyldiglycyl-S-benzyl-L-cysteinyldiglycyl-S-benzyl-L-cysteinylglycylglycinamide

C₅₆H₇₁N₁₃O₁₂S₄*BrH

N-acetyldiglycyl-S-benzyl-L-cysteinylglycylglycinamide

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