N-benzyloxycarbonyl-S-benzyl-L-cysteinylglycylglycine-amide

Base Information

• Chemical Name: N-benzyloxycarbonyl-S-benzyl-L-cysteinylglycylglycine-amide
• CAS No.: 75509-31-8
• Molecular Formula: C₂₂H₂₆N₄O₅S
• Molecular Weight: 458.538
• Mol file: 75509-31-8.mol

Synonyms:N-benzyloxycarbonyl-S-benzyl-L-cysteinylglycylglycine-amide

Chemical Property of N-benzyloxycarbonyl-S-benzyl-L-cysteinylglycylglycine-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyloxycarbonyl-S-benzyl-L-cysteinylglycylglycine-amide

There total 1 articles about N-benzyloxycarbonyl-S-benzyl-L-cysteinylglycylglycine-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-benzyloxycarbonyl-S-benzyl-L-cysteine succinimido-ester (3401-57-8) + N-glycyl-glycine amide; acetate (51814-59-6) → N-benzyloxycarbonyl-S-benzyl-L-cysteinylglycylglycine-amide (75509-31-8)

Guidance literature:

In 1,4-dioxane; for 24h; Ambient temperature;

DOI:10.1039/DT9800001228

Reference yield: 91.0%

N-benzyloxycarbonyl-S-benzyl-L-cysteinylglycylglycine-amide (75509-31-8) → S-benyl-L-cysteinylglycylglycinamide (75509-33-0)

Guidance literature:

With hydrogen bromide; In acetic acid; at 20 ℃; for 0.833333h;

DOI:10.1039/DT9800001228

Reference yield:

N-benzyloxycarbonyl-S-benzyl-L-cysteinylglycylglycine-amide (75509-31-8) → N-benzyloxycarbonyl-S-benzyl-L-cysteinyldiglycyl-S-benzyl-L-cysteinyldiglycyl-S-benzyl-L-cysteinyldiglycyl-S-benzyl-L-cysteinylglycylglycinamide (75509-40-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 91 percent / 45percent HBr / acetic acid / 0.83 h / 20 °C

2: 70 percent / dioxane / 24 h / Ambient temperature

3: 85 percent / 45percent HBr / acetic acid / 0.83 h / 20 °C

4: 87 percent / acetic acid; dimethylformamide / Ambient temperature

5: 45percent HBr / acetic acid / 0.83 h / 20 °C

6: 87 percent / triethylamine / dimethylformamide; acetic acid / Ambient temperature

With hydrogen bromide; triethylamine; In 1,4-dioxane; acetic acid; N,N-dimethyl-formamide;

DOI:10.1039/DT9800001228

upstream raw materials:

N-benzyloxycarbonyl-S-benzyl-L-cysteine succinimido-ester

N-glycyl-glycine amide; acetate

Downstream raw materials:

S-benyl-L-cysteinylglycylglycinamide

N-benzyloxycarbonyl-S-benzyl-L-cysteinyldiglycyl-S-benzyl-L-cysteinyldiglycyl-S-benzyl-L-cysteinyldiglycyl-S-benzyl-L-cysteinylglycylglycinamide

N-acetyldiglycyl-S-benzyl-L-cysteinyldiglycyl-S-benzyl-L-cysteinyldiglycyl-S-benzyl-L-cysteinyldiglycyl-S-benzyl-L-cysteinylglycylglycinamide

C₅₆H₇₁N₁₃O₁₂S₄*BrH